Evidence map›Paper›PMID 32066660›Full record

ArticleTranslational psychiatry2020

Personality, lifestyle and job satisfaction: causal association between neuroticism and job satisfaction using Mendelian randomisation in the UK biobank cohort.

Gull Rukh, Junhua Dang, Gaia Olivo, Diana-Maria Ciuculete, Mathias Rask-Andersen, Helgi Birgir Schiöth

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Gull RukhDepartment of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden. gull.rukh@neuro.uu.se.ORCID http://orcid.org/0000-0003-0000-7694
Junhua DangDepartment of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
Gaia OlivoDepartment of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-7514-4493
Diana-Maria CiuculeteDepartment of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
Mathias Rask-AndersenDepartment of Immunology, Genetics and Pathology, Medical Genetics and Genomics, Uppsala University, Uppsala, Sweden.
Helgi Birgir SchiöthDepartment of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
Uppsala University · SE

Funding

Forskningsrådet om Hälsa, Arbetsliv och Välfärd (Swedish Research Council for Health, Working Life and Welfare) 2018-06664
6 · The paper itself

Abstract

Job-related stress has been associated with poor health outcomes but little is known about the causal nature of these findings. We employed Mendelian randomisation (MR) approach to investigate the causal effect of neuroticism, education, and physical activity on job satisfaction. Trait-specific genetic risk score (GRS) based on recent genome wide association studies were used as instrumental variables (IV) using the UK Biobank cohort (N = 315,536). Both single variable and multivariable MR analyses were used to determine the effect of each trait on job satisfaction. We observed a clear evidence of a causal association between neuroticism and job satisfaction. In single variable MR, one standard deviation (1 SD) higher genetically determined neuroticism score (4.07 units) was associated with -0.31 units lower job satisfaction (95% confidence interval (CI): -0.38 to -0.24; P = 9.5 × 10

Indexed as

Genome-Wide Association StudyJob SatisfactionBiological Specimen BanksHumansLife StyleNeuroticismPersonalityUnited Kingdom

Identifiers

PMID32066660
PMCPMC7026032
OpenAlexW3002283080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.