Evidence map›Paper›PMID 32066633›Full record

SynthesisJournal of medical genetics2020

Association between genetic polymorphisms and endometrial cancer risk: a systematic review.

Cemsel Bafligil, Deborah J Thompson, Artitaya Lophatananon, Miriam J Smith, Neil Aj Ryan, Anie Naqvi, D Gareth Evans, Emma J Crosbie

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Investigation ofTurkish journal of obstetrics and gynecology · 2024
    Article
  10. Review
  11. Article
  12. Endometrial Cancer Risk Among GermlineJCO precision oncology · 2023
    Review
  13. Review
  14. Review
  15. Alternative splicing ofJournal of gynecologic oncology · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cemsel BafligilDivision of Cancer Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-2365-1194
Deborah J ThompsonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Artitaya LophatananonDivision of Population Health, University of Manchester, Manchester, UK.
Miriam J SmithDivision of Evolution and Genomic Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-3184-0817
Neil Aj RyanDivision of Cancer Sciences, University of Manchester, Manchester, UK.
Anie NaqviUniversity of Manchester Medical School, Manchester, UK.
D Gareth EvansDivision of Evolution and Genomic Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-8482-5784
Emma J CrosbieDivision of Cancer Sciences, University of Manchester, Manchester, UK emma.crosbie@manchester.ac.uk.ORCID 0000-0003-0284-8630
University of Manchester · GBUniversity of Cambridge · GB

Funding

Department of Health NIHR-CS-012-009Medical Research Council MR/M018431/1
6 · The paper itself

Abstract

introductionEndometrial cancer is one of the most commonly diagnosed cancers in women. Although there is a hereditary component to endometrial cancer, most cases are thought to be sporadic and lifestyle related. The aim of this study was to systematically review prospective and retrospective case-control studies, meta-analyses and genome-wide association studies to identify genomic variants that may be associated with endometrial cancer risk.

methodsWe searched MEDLINE, Embase and CINAHL from 2007 to 2019 without restrictions. We followed PRISMA 2009 guidelines. The search yielded 3015 hits in total. Following duplicate exclusion, 2674 abstracts were screened and 453 full-texts evaluated based on our pre-defined screening criteria. 149 articles were eligible for inclusion.

resultsWe found that single nucleotide polymorphisms (SNPs) in

conclusionEndometrial cancer risk may be influenced by SNPs in genes involved in cell survival, oestrogen metabolism and transcriptional control. Larger cohorts are needed to identify more variants with genome-wide significance.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyAromataseeIF-2 KinaseEndometrial NeoplasmsFemaleHepatocyte Nuclear Factor 1-betaHumansKruppel-Like Transcription FactorsPolymorphism, Single NucleotideProspective StudiesProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-mycRisk FactorsSOXC Transcription FactorsAromataseCYP19A1 protein, humanEIF2AK1 protein, humaneIF-2 Kinaseerythroid Kruppel-like factorHepatocyte Nuclear Factor 1-betaHNF1B protein, humanKruppel-Like Transcription FactorsMDM2 protein, humanMYC protein, humanProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-mycSOX4 protein, humanSOXC Transcription Factorsendometrial cancergenetic epidemiologyrisk predictionsingle nucleotide polymorphism (SNP)systematic review

Identifiers

PMID32066633
PMCPMC7476276
OpenAlexW2998222935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.