Observational studyBMJ open2020
Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study.
Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02334891 (Kyoto Congestive Heart Failure Study), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kyoto Congestive Heart Failure Study
Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Factors Associated With Improvement in Activities of Daily Living in Patients With Cardiovascular Disease in a Japanese Community Rehabilitation Ward: A Multicenter Prospective Study.Circulation reports · 2026Article
- Improving Physical Performance During Hospitalization Has an Impact on Reducing the Risk of Clinical Events in Frail Older Patients With Acutely Decompensated Heart Failure.Circulation reports · 2026Article
- Impact of Tailored Multidisciplinary Cardiac Rehabilitation on Patients With Cardiovascular Diseases and Multimorbidity in Convalescent Rehabilitation Hospitals in Japan - A Multicenter, Prospective Observational Study.Circulation reports · 2025Article
- Factors involved in the development of hospital-acquired conditions in older patients in acute care settings: a scoping review.BMC health services research · 2025Article
- Improving Respiratory Muscle Strength and Overall Function in Patients With Cardiovascular Disease Through Rehabilitation Hospitals.Cardiology research · 2024Article
- Effect of in-patient cardiac rehabilitation at rehabilitation hospital for cardiology patients: two-center trial.Heart and vessels · 2024Article
- Acute Decompensated Heart Failure in the Elderly: An Observational Study in a Regional Victorian Hospital.Cureus · 2024Article
- Relationship Between the Frequency and Duration of Physical Therapy and Hospitalization-associated Disability Among Geriatric Patients with Heart Failure.Physical therapy research · 2024Article
- Examination of factors related to the performance index of patients with cardiovascular disease in a convalescent rehabilitation hospital.Japanese journal of comprehensive rehabilitation science · 2024Article
- Implication of different frailty criteria in older people with atrial fibrillation: a prospective cohort study.BMC geriatrics · 2023Article
- A comparison between hospital follow-up and collaborative follow-up in patients with acute heart failure.ESC heart failure · 2023Observational
- Association between Hospital-acquired Disability and Clinical Outcomes in Older Patients Who Underwent Cardiac Surgical.Physical therapy research · 2023Article
- Application of the (fr)AGILE scale in the evaluation of multidimensional frailty in elderly inpatients from internal medicine wards: a cross-sectional observational study.Frontiers in aging neuroscience · 2023Article
- Prognostic importance of improving hepatorenal function during hospitalization in acute decompensated heart failure.ESC heart failure · 2022Article
- Public assistance in patients with acute heart failure: a report from the KCHF registry.ESC heart failure · 2022Observational
- Mortality from Heart Failure with Mid-Range Ejection Fraction.Arquivos brasileiros de cardiologia · 2022Article
- Effectiveness of Yiqi Fumai lyophilized injection for acute heart failure: Rationale and design of the AUGUST-AHF cohort study.Frontiers in cardiovascular medicine · 2022Article
- Association between induction of the self-management system for preventing readmission and disease severity and length of readmission in patients with heart failure.BMC research notes · 2021Article
- Hyponatremia in the frail.Journal of frailty, sarcopenia and falls · 2021Article
- Risk Factors and Clinical Outcomes of Nonhome Discharge in Patients With Acute Decompensated Heart Failure: An Observational Study.Journal of the American Heart Association · 2021Observational
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the prevalence and risk factors of functional decline during hospitalisation and its relationship with postdischarge outcomes in very old patients with acute decompensated heart failure (ADHF) hospitalisation.
designProspective cohort study between 1 October 2014 and 31 March 2016.
settingA physician-initiated, multicentre study of consecutive patients admitted for ADHF in 19 hospitals throughout Japan.
participantsAmong 3555 patients hospitalised for ADHF (median age (IQR), 80 (71-86) years; 1572 (44%) women), functional decline during the index hospitalisation occurred in 528 patients (15%). PRIMARY AND SECONDARY OUTCOMES: The primary outcome measure was a composite of all-cause death or heart failure (HF) hospitalisation after discharge. The secondary outcome measures were all-cause death, HF hospitalisation, and a composite of all-cause death or all-cause hospitalisation.
resultsThe independent risk factors for functional decline included age ≥80 years (OR 2.71; 95% CI 2.09 to 3.51), female (OR 1.32; 95% CI 1.05 to 1.67), prior stroke (OR 1.67; 95% CI 1.28 to 2.19), dementia (OR 2.26; 95% CI 1.74 to 2.95), ambulatory before admission (OR 1.74; 95% CI 1.29 to 2.35), elevated body temperature (OR 1.91; 95% CI 1.31 to 2.79), New York Heart Association class III or IV on admission (OR 1.54; 95% CI 1.07 to 2.22), decreased albumin levels (OR 1.76; 95% CI 1.32 to 2.34), hyponatraemia (OR 1.49; 95% CI 1.10 to 2.03) and renal dysfunction (OR 1.55; 95% CI 1.22 to 1.98), after multivariable adjustment. The cumulative 1-year incidence of the primary outcome in the functional decline group was significantly higher than that in the no functional decline group (50% vs 31%, log-rank p<0.001). After adjusting for baseline characteristics, the higher risk of the functional decline group relative to the no functional decline group remained significant (adjusted HR 1.46; 95% CI 1.24 to 1.71; p<0.001).
conclusionsIndependent risk factors of functional decline in very old patients with ADHF were related to both frailty and severity of HF. Functional decline during ADHF hospitalisation was associated with unfavourable postdischarge outcomes. TRIAL REGISTRATION NUMBER: NCT02334891, UMIN000015238.
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