Trial reportBMJ open2020
Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery.
Trial report in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prophylactic measures to prevent cerebral oxygen desaturation events in elective beach-chair position shoulder surgeries: a systematic review and meta-analysis.Korean journal of anesthesiology · 2021Pooled it
- Effect of intraoperative CO₂-targeted ventilation on postoperative grip strength recovery in older patients undergoing open abdominal surgery: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Effect of optimizing cerebral oxygen saturation on postoperative delirium in older patients undergoing one-lung ventilation for thoracoscopic surgery.The Journal of international medical research · 2024Trial
- Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial.BMC anesthesiology · 2024Trial
- Two-lung ventilation with artificial pneumothorax on cerebral desaturation and early postoperative cognitive outcome: a randomized controlled trial.Surgical endoscopy · 2024Trial
- Impact of Remimazolam versus Sevoflurane Anesthesia on Cerebral Oxygenation and Intracranial Pressure during Gynecological Laparoscopy with Mild Hypercapnia.Medical science monitor : international medical journal of experimental and clinical research · 2023Trial
- Effects of targeted mild hypercapnia versus normocapnia on cerebral oxygen saturation in patients undergoing laparoscopic hepatectomy under low central venous pressure: a prospective, randomized controlled study.BMC anesthesiology · 2023Trial
- Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications.BMC anesthesiology · 2022Trial
- Alveolar Recruitment Maneuver Reduces Cerebral Oxygen Saturation and Cerebral Blood Flow Velocity in Patients During Carotid Endarterectomy.Medical science monitor : international medical journal of experimental and clinical research · 2021Trial
- The safety and feasibility of non-intubated versus intubated video-assisted thoracic surgery in NSCLC patients after neoadjuvant therapy: a propensity score matching study.Journal of thoracic disease · 2026Article
- Effects of controlled low central venous pressure on organ function during hepatectomy: Current progress.The Journal of international medical research · 2026Review
- Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi-Centre Cohort Study of 1014 Patients.Acta anaesthesiologica Scandinavica · 2026Observational
- McKeown minimally invasive esophagectomy under discontinuous spontaneous ventilating anesthesia by laryngeal mask: a retrospective non-inferiority cohort study.Journal of thoracic disease · 2025Article
- Double-lumen tubes verus single-lumen tube in patients undergoing minimally invasive cardiac surgery: a randomised, controlled clinical trial.Frontiers in cardiovascular medicine · 2025Article
- Research progress on the interaction between multiple organ-brain axes and perioperative neurocognitive disorders: a narrative review.Frontiers in aging neuroscience · 2025Review
- Progress on the Effects of Permissive Hypercapnia on the CNS During the Intraoperative Period: A Narrative Review.Cureus · 2024Review
- Impact of Permissive Hypercapnia on Postoperative Early Plasma Neurofilament Light Chain in Elderly Patients Undergoing Laparoscopic Surgery: A Prospective, Randomized Controlled Trial.Therapeutics and clinical risk management · 2024Article
- Article
- The impact of tubeless anesthesia versus intubated anesthesia on cerebral oxygen saturation and postoperative cognitive function in patients undergoing video-assisted thoracoscopic surgery: a randomized trial.Journal of thoracic disease · 2022Article
- Cerebral Tissue Oxygen Saturation Is Enhanced in Patients following Transcatheter Aortic Valve Implantation: A Retrospective Study.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe effects of hypercapnia on regional cerebral oxygen saturation (rSO
designA prospective, randomised, controlled trial in adult participants undergoing elective major surgery.
settingA single tertiary centre in Heidelberg, Victoria, Australia.
participants40 participants were randomised to either a TMH or TN group (20 to each).
interventionsTMH (partial pressure of carbon dioxide in arterial blood, PaCO PRIMARY AND SECONDARY OUTCOME MEASURES: The primary endpoint was the absolute difference between the two groups in percentage change in rSO
resultsThe absolute difference between the two groups in percentage change in rSO
conclusionTMH was associated with a stable increase in rSO TRIAL REGISTRATION NUMBER: The Australian New Zealand Clinical Trials Registry (ACTRN12616000320459).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.