ArticleBMJ open respiratory research2020
Asthma is associated with frailty among community-dwelling adults: the GAZEL cohort.
Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Strength of association between comorbidities and asthma: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Development and validation of a long-term survival prediction model for older adults with asthma.Archives of public health = Archives belges de sante publique · 2026Article
- Causal effects of physical activity and frailty on pneumothorax risk: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Exploring the association between asthma and frailty: a cross-sectional and a bidirectional Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Association between frailty transitions and chronic lung disease incidence: findings from four national cohort studies.BMC public health · 2025Article
- Relationship of the oxidative balance score with the risk of frailty and mortality in patients with asthma: a mediation analysis of NHANES.BMC pulmonary medicine · 2025Article
- Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study.BMJ open respiratory research · 2025Article
- Association between a frailty index derived from laboratory tests and clinical outcomes in critical care patients with asthma: a retrospective study based on the MIMIC-IV database.Frontiers in medicine · 2025Article
- The causal association between asthma and the risk of frailty: A two-sample Mendelian randomization study.Aging clinical and experimental research · 2024Article
- Association between Frailty and Asthma.Medicina (Kaunas, Lithuania) · 2024Article
- Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases.International forum of allergy & rhinology · 2024Article
- Causal association between genetically predicted circulating immune cell counts and frailty: a two-sample Mendelian randomization study.Frontiers in immunology · 2024Article
- Association of Physical Activity with Asthma and Chronic Obstructive Pulmonary Disease and Mediation of Frailty: Mendelian Randomization Analyses.International journal of chronic obstructive pulmonary disease · 2024Article
- Understanding the Causes of Frailty Using a Life-Course Perspective: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Frailty Prevalence and Association with Clinical Outcomes in Interstitial Lung Disease, Asthma, and Pleural Disease.Geriatrics (Basel, Switzerland) · 2023Review
- Frailty in asthma-COPD overlap: a cross-sectional study of association and risk factors in the NHANES database.BMJ open respiratory research · 2023Article
- The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study.Frontiers in medicine · 2023Article
- Handgrip strength as a diagnostic tool for frailty risk in elderly patients with moderate to severe asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023Article
- Epidemiological status and associated factors of frailty and pre-frailty in older adults with asthma in China: A national cross-sectional study.Frontiers in public health · 2023Article
- Microbiome First Medicine in Health and Safety.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEarly management of chronic respiratory diseases (CRDs) and frailty have been identified as key targets towards healthy ageing, but the association between CRDs and frailty has been poorly investigated. We studied the association between asthma and frailty in adults of the GAZEL cohort using different definitions of asthma over the 26 years of follow-up.
methodsCurrent asthma definitions are based on yearly self-reports of symptoms or medication (in 2015, constant reports or at least one report between 1990 and 2015), or on a detailed respiratory symptoms questionnaire in 2002. Frailty definition is based on weakness, fatigue, unintentional weight loss, low physical activity and mobility in 2015. Frail participants had three criteria or more, pre-frail 1 or 2, and robust 0. Multinomial regression models adjusted for age, sex, body mass index, smoking, education, marital status and comorbidities were performed.
resultsIn 2015, 12 345 adults (73% men, 61 to 77 years old) were included: 3% of them reported current asthma, 1.6% had constant reports during the follow-up and 9% reported current asthma at least once. In 2015, 6% were frail, 34% pre-frail and 13% of current asthmatics and 6% of non-asthmatics were frail (adjusted OR (aOR) 2.19 (1.44 to 3.34)). Significant associations were also found with the 2002 definition (aOR 2.24 (1.73 to 2.90)), constant reports (aOR 3.67 (1.70 to 7.93)) or at least once (aOR 1.50 (1.15 to 1.98)). Current asthma was also associated with pre-frailty with the 2002 definition (aOR 1.46 (1.26 to 1.68)). DISCUSSION: Participants with asthma had increased risk of frailty. A better understanding of their relationship could help to define and evaluate strategies for a better ageing of asthmatics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.