ArticleBMC genomics2020
A 14-bp insertion in endothelin receptor B-like (EDNRB2) is associated with white plumage in Chinese geese.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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18 citing papers in PubMed, 33 citations in OpenAlex.
- Ancient Plumage Colour Genetics Reveal Goose Domestication and Hybridization.Animal genetics · 2026Article
- Sex-Linked Dilution Colour in the European Domestic Goose Indicated To Be a 1-Bp Deletion in the Melan-A Gene.Animal genetics · 2026Article
- The Mottling Phenotype in Chickens Shows Genetic Heterogeneity and Is Caused by Mutations at the EDNRB2 Locus.Animal genetics · 2026Article
- Review
- Widespread Variation in EDNRB2 Is Associated With Diverse Melanin Loss Phenotypes Across Avian Species.Molecular biology and evolution · 2025Article
- Identification of key candidate genes and marker metabolites of melanin synthesis in black-bone chicken.BMC genomics · 2025Article
- Widespread variation inbioRxiv : the preprint server for biology · 2025Article
- Article
- A high-quality assembly revealing the PMEL gene for the unique plumage phenotype in Liancheng ducks.GigaScience · 2025Article
- Identification of Differentially Expressed Genes and microRNAs in the Gray and White Feather Follicles of Shitou Geese.Animals : an open access journal from MDPI · 2024Article
- Insights into genetic diversity and phenotypic variations in domestic geese through comprehensive population and pan-genome analysis.Journal of animal science and biotechnology · 2023Article
- Stripes and loss of color in ball pythons (Python regius) are associated with variants affecting endothelin signaling.G3 (Bethesda, Md.) · 2023Article
- Association analysis of melanophilin (Archives animal breeding · 2023Article
- Chromosome-level genome and population genomics reveal evolutionary characteristics and conservation status of Chinese indigenous geese.Communications biology · 2022Article
- Article
- Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia).Molecular biology and evolution · 2021Article
- Genome-wide association analysis reveals that EDNRB2 causes a dose-dependent loss of pigmentation in ducks.BMC genomics · 2021Article
- Transcriptome Reveals Multi Pigmentation Genes Affecting Dorsoventral Pattern in Avian Body.Frontiers in cell and developmental biology · 2020Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGang goose is a native species with gray plumage in Sichuan, China. As a result of overhunting, the number of gray Gang geese has decreased dramatically. To keep the species from extinction, conservation work for Gang geese was undertaken. In the process of pure breeding of gray Gang geese, approximately 2% of the offspring of each generation were white. This study aims to explain the genetic mechanism of this phenomenon and provide reliable molecular markers for goose-related plumage color breeding.
resultsWe used the method of pooled whole genome sequencing and Fst (fixation statistics) to identify the differentiation degree of alleles between gray Gang geese and white Gang geese from their offspring. In this way, EDNRB2, a key gene that affects the migration of melanoblasts, was identified. Then, the transcriptome was sequenced for the two geese plumage color populations, and the DEGs (differentially expressed genes) were analyzed. The results indicated that EDNRB2, as a possible candidate gene, had a significantly differential mRNA expression. In addition, a 14-bp insertion (NW_013185915.1: g. 750,748-750,735 insertion. CACAGGTGAGCTCT) in exon 3 of EDNRB2 was analyzed and found to have a significant association between gray geese and Chinese white breeds (P = 0.00), while this mutation was not found in European geese. Meanwhile, the insertion was homozygous in all the white geese we detected and heterozygous in gray geese, indicating that this mutation is recessive. Furthermore, this 14-bp insertion leads to a frameshift mutation in the EDNRB2 coding region and nonsense-mediated mRNA decay.
conclusionOur study strongly suggests that the 14-bp insertion in exon 3 of the EDNRB2 gene is associated with the white plumage phenotype in Chinese geese. This study is the first to investigate the relationship between EDNRB2 and white plumage in geese.
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