Evidence map›Paper›PMID 32065988›Full record

ArticleChild abuse & neglect2020

Social supports moderate the effects of child adversity on neural correlates of threat processing.

Nicholas F Wymbs, Catherine Orr, Matthew D Albaugh, Robert R Althoff, Kerry O'Loughlin, Hannah Holbrook, Hugh Garavan, Janitza L Montalvo-Ortiz, Stewart Mostofsky, James Hudziak and 1 more

Abstract read
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In one paragraph

Article in Child abuse & neglect, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  9. Interaction of perceived social support and childhood maltreatment on limbic responsivity towards negative emotional stimuli in healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicholas F WymbsCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA.
Catherine OrrSwinburne University of Technology, John St, Hawthorn, 3122, Australia; Vermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Matthew D AlbaughVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Robert R AlthoffVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Kerry O'LoughlinVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Hannah HolbrookVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Hugh GaravanVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Janitza L Montalvo-OrtizDepartment of Psychiatry, Yale University, 300 George St., Suite 901, New Haven, CT 06511, USA.
Stewart MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA; Department of Neurology, Johns Hopkins School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA.
James HudziakVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, UHC Campus, Arnold 3, 1 South Prospect, Burlington, VT 05401, USA.
Joan KaufmanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA; Center for Child and Family Traumatic Stress, Kennedy Krieger Institute, 1741 Ashland Avenue, Baltimore, MD 21205, USA. Electronic address: joan.kaufman@kennedykrieger.org.

Funding

RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
Social adversities, epigenetics, and the obesity epidemicR01MD011746 · NIMHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE · 2017 to 2021
$4.4M
Risk and Resilience in Maltreated ChildrenR01MH098073 · NIMH · YALE UNIVERSITY · PI HUDZIAK, JAMES J., KAUFMAN, JOAN R. · 2012 to 2015
$3.0M
NIMHD NIH HHS R01 MD011746NIMH NIH HHS R01 MH098073NIMH NIH HHS T32 MH014276
6 · The paper itself

Abstract

backgroundChild abuse and other forms of adversity are associated with alterations in threat processing and emotion regulation brain circuits.

objectiveThe goal of the current investigation is to determine if the availability of positive social support can ameliorate the negative impact of adversity on these brain systems. PARTICIPANTS AND

settingSubjects included 55 children ages 7-16 (X = 11.8, SD = 2.0). Approximately one-third of the cohort had no significant history of adversity, one-third had a history of moderate adversity, and one-third had a history of severe adversity. Brain imaging was conducted at the University of Vermont using a 3.0 T Philips scanner.

methodsThe Emotional Go-NoGo task with fearful and calm facial stimuli was used to assess the neural correlates of threat processing and emotion regulation in children during functional magnetic resonance imaging (fMRI). Dimensional measures of anxiety, social supports, and children's adverse experiences were also obtained.

resultsA conjunction analysis was used to test if trauma-related brain activation in responding to fearful vs. calm targets was impacted by social support. This approach identified multiple activation foci, including a cluster extending from the left amygdala to several other key brain regions involved in emotion regulation, including the orbitofrontal cortex, anterior cingulate cortex (ACC), anterior insula, nucleus accumbens, and frontal pole (Family Wise Error (FWE) correction, p < 0.05).

conclusionsGreater social support may reduce the effect that adversity has on neural processing of threat stimuli, consistent with the protective role of positive supports in promoting resilience and recovery demonstrated in the literature.

Indexed as

Social SupportAdolescentBrainChildChild AbuseFemaleHumansMaleAdverse childhood experiencesChild maltreatmentNeuroimagingSocial supportThreat processing

Identifiers

PMID32065988
PMCPMC8060780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.