ArticleCortex; a journal devoted to the study of the nervous system and behavior2020
Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Boston NamingTest performance in mild cognitive impairment: a meta-analysis.BMC neurology · 2026Pooled it
- Immediate to longer-term neurophysiological impact of acute neural network disruption.medRxiv : the preprint server for health sciences · 2026Article
- Contralateral language network integration predicts and protects against naming decline after temporal lobe resection.Epilepsia · 2026Article
- A Novel Approach to Map the Causal Impact of Brain Stimulation on Semantic Processing With Language Models.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Article
- Disentangling phonology from phonological short-term memory in Alzheimer's disease phenotypes.Alzheimer's research & therapy · 2025Article
- Drawing from name in semantic dementia reveals graded object knowledge representations in anterior temporal lobe.Memory & cognition · 2025Article
- Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Neural manifolds carry reactivation of phonetic representations during semantic processing.bioRxiv : the preprint server for biology · 2024Article
- Immediate neural impact and incomplete compensation after semantic hub disconnection.Nature communications · 2023Article
- Diffusion magnetic resonance imaging connectome features are predictive of functional lateralization of semantic processing in the anterior temporal lobes.Human brain mapping · 2023Article
- Task modulation of spatiotemporal dynamics in semantic brain networks: An EEG/MEG study.NeuroImage · 2022Article
- Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients.Frontiers in human neuroscience · 2022Article
- Frontotemporal dementia: A unique window on the functional role of the temporal lobes.Handbook of clinical neurology · 2022Review
- Phonemic restoration in Alzheimer's disease and semantic dementia: a preliminary investigation.Brain communications · 2022Article
- Advances in neuroimaging to support translational medicine in dementia.Journal of neurology, neurosurgery, and psychiatry · 2021Review
- In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
- Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
In the healthy human brain, the processing of language is strongly lateralised, usually to the left hemisphere, while the processing of complex non-linguistic sounds recruits brain regions bilaterally. Here we asked whether the anterior temporal lobes, strongly implicated in semantic processing, are critical to this special treatment of spoken words. Nine patients with semantic dementia (SD) and fourteen age-matched controls underwent magnetoencephalography and structural MRI. Voxel based morphometry demonstrated the stereotypical pattern of SD: severe grey matter loss restricted to the anterior temporal lobes, with the left side more affected. During magnetoencephalography, participants listened to word sets in which identity and meaning were ambiguous until word completion, for example PLAYED versus PLATE. Whereas left-hemispheric responses were similar across groups, patients demonstrated increased right hemisphere activity 174-294 msec after stimulus disambiguation. Source reconstructions confirmed recruitment of right-sided analogues of language regions in SD: atrophy of anterior temporal lobes was associated with increased activity in right temporal pole, middle temporal gyrus, inferior frontal gyrus and supramarginal gyrus. Overall, the results indicate that anterior temporal lobes are necessary for normal and efficient lateralised processing of word identity by the language network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.