Evidence map›Paper›PMID 32065769›Full record

Trial reportCirculation2020

Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients With Primary Breast Cancer: A Randomized Controlled Trial.

Jessica M Scott, Samantha M Thomas, Jeffrey M Peppercorn, James E Herndon, Pamela S Douglas, Michel G Khouri, Chau T Dang, Anthony F Yu, Diane Catalina, Cristi Ciolino and 4 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01186367 (Exercise Intensity Trial), which is not on this map. Cited by 40 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 7 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01186367 nacompletednot on this map

Exercise Intensity Trial (EXCITE): A Randomized Trial Comparing the Effects of Linear Versus Nonlinear Aerobic Training in Women With Operable Breast Cancer

TypeinterventionalSponsorMemorial Sloan Kettering Cancer CenterRan2010 to 2023Enrolled174ConditionsBreast CancerArmsLinear Aerobic Training, Nonlinear Aerobic Training, Progressive Stretching, Cardiopulmonary exercise test (CPET), Blood draws
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  6. Effect of aerobic exercise on cardiotoxic outcomes in women with breast cancer undergoing anthracycline or trastuzumab treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  8. A Co-clinical Trial of Exercise Therapy in Breast Cancer Prevention.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Jessica M ScottMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Samantha M ThomasDuke University Medical Center, Durham, NC (S.M.T., J.E.H., P.S.D., M.G.K.).
Jeffrey M PeppercornWeill Cornell Medical College, New York, NY (J.M.S., C.T.D., L.W.J.).
James E HerndonDuke University Medical Center, Durham, NC (S.M.T., J.E.H., P.S.D., M.G.K.).
Pamela S DouglasDuke University Medical Center, Durham, NC (S.M.T., J.E.H., P.S.D., M.G.K.).
Michel G KhouriDuke University Medical Center, Durham, NC (S.M.T., J.E.H., P.S.D., M.G.K.).
Chau T DangMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Anthony F YuMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Diane CatalinaMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Cristi CiolinoMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Catherine CapaciMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Meghan G MichalskiMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Neil D EvesUniversity of British Columbia, Kelowna, British Columbia, Canada (N.D.E.).
Lee W JonesMemorial Sloan Kettering Cancer Center, New York, NY (J.M.S., C.T.D., A.F.Y., D.C., C.C., C.C., M.G.M., L.W.J.).
Memorial Sloan Kettering Cancer Center · USDuke University · USCornell University · USKelowna General Hospital · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Randomized Trial of Optimal Type of Aerobic Training in Breast CancerR01CA142566 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2010 to 2017
$2.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA142566
6 · The paper itself

Abstract

backgroundCurrent exercise guidelines for clinical populations recommend an exercise therapy (ET) prescription of fixed intensity (moderate), duration (40-50 minutes per session), and volume (120-160 min/wk). A critical overarching element of exercise programming that has received minimal attention is dose scheduling. We investigated the tolerability and efficacy of 2 exercise training dose regimens on cardiorespiratory fitness and patient-reported outcomes in patients with posttreatment primary breast cancer.

methodsUsing a parallel-group randomized trial, we randomly allocated 174 postmenopausal patients (2.8 years after adjuvant therapy) with impaired peak oxygen consumption (VO

resultsNo serious adverse events were observed. Mean attendance was 64%, 75%, and 80% for attention control, LET, and NLET, respectively. In intention-to-treat analysis, VO

conclusionsShort-term exercise training, independently of dosing schedule, is associated with modest improvements in cardiorespiratory fitness in patients previously treated for early-stage breast cancer. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01186367.

Indexed as

Breast NeoplasmsCardiorespiratory FitnessExercise TherapyOxygen ConsumptionQuality of LifeAgedFemaleHumansMiddle Agedbreast neoplasmscardiorespiratory fitnessexercise

Identifiers

PMID32065769
PMCPMC7032604
OpenAlexW3006536837

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.