ArticleEpilepsia2020
Early epilepsy in children with Zika-related microcephaly in a cohort in Recife, Brazil: Characteristics, electroencephalographic findings, and treatment response.
Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Neurological complications of Zika virus and their impact on quality of life: a narrative review.Tropical medicine and health · 2026Review
- Clinical, Neuroimaging and Video Electroencephalography Findings in Children With Congenital Zika Syndrome: An Analysis From a Neurorehabilitation Centre.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026Article
- All-Cause and Cause-Specific Mortality in Children With Congenital Zika Syndrome in Brazil.JAMA network open · 2025Article
- Characterization of 843 children with Zika-related microcephaly in the first three years of life: An individual participant data meta-analysis of 12 cohorts in the Zika Brazilian Cohorts consortium.PLOS global public health · 2025Article
- A zebrafish-based in vivo model of Zika virus infection unveils alterations of the glutamatergic neuronal development and NS4A as a key viral determinant of neuropathogenesis.PLoS pathogens · 2024Article
- Understanding the multidimensional neurodevelopmental outcomes in children after congenital Zika virus exposure.Pediatric research · 2024Review
- In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection.EMBO molecular medicine · 2024Article
- Zika Virus-A Reemerging Neurotropic Arbovirus Associated with Adverse Pregnancy Outcomes and Neuropathogenesis.Pathogens (Basel, Switzerland) · 2024Review
- Clinical spectrum of congenital Zika virus infection in Brazil: Update and issues for research development.Revista da Sociedade Brasileira de Medicina Tropical · 2024Review
- Article
- PhenoExam: gene set analyses through integration of different phenotype databases.BMC bioinformatics · 2022Article
- Neurological evaluation of microcephalic children with Zika syndrome and congenital cytomegalovirus infection.eNeurologicalSci · 2022Article
- Article
- Mortality from Congenital Zika Syndrome - Nationwide Cohort Study in Brazil.The New England journal of medicine · 2022Article
- Neighbourhood-level income and Zika virus infection during pregnancy in Recife, Pernambuco, Brazil: an ecological perspective, 2015-2017.BMJ global health · 2021Article
- The legacy of ZikaPLAN: a transnational research consortium addressing Zika.Global health action · 2021Review
- A guide for the use of fNIRS in microcephaly associated to congenital Zika virus infection.Scientific reports · 2021Observational
- The Microcephaly Epidemic Research Group Paediatric Cohort (MERG-PC): A Cohort Profile.Viruses · 2021Article
- Pediatric neurodevelopment by prenatal Zika virus exposure: a cross-sectional study of the Microcephaly Epidemic Research Group Cohort.BMC pediatrics · 2020Article
- Article
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15 authors.
Funding
Abstract
objectiveTo estimate the incidence of epilepsy in children with Zika-related microcephaly in the first 24 months of life; to characterize the associated clinical and electrographic findings; and to summarize the treatment responses.
methodsWe followed a cohort of children, born during the 2015-2016 Zika virus (ZIKV) epidemic in Brazil, with congenital microcephaly and evidence of congenital ZIKV infection on neuroimaging and/or laboratory testing. Neurological assessments were performed at ≤3, 6, 12, 15, 18, 21, and 24 months of life. Serial electroencephalograms were performed over the first 24 months.
resultsWe evaluated 91 children, of whom 48 were female. In this study sample, the cumulative incidence of epilepsy was 71.4% in the first 24 months, and the main type of seizure was infantile spasms (83.1%). The highest incidence of seizures occurred between 3 and 9 months of age, and the risk remained high until 15 months of age. The incidence of infantile spasms peaked between 4 and 7 months and was followed by an increased incidence of focal epilepsy cases after 12 months of age. Neuroimaging results were available for all children, and 100% were abnormal. Cortical abnormalities were identified in 78.4% of the 74 children evaluated by computed tomography and 100% of the 53 children evaluated by magnetic resonance imaging. Overall, only 46.1% of the 65 children with epilepsy responded to treatment. The most commonly used medication was sodium valproate with or without benzodiazepines, levetiracetam, phenobarbital, and vigabatrin. SIGNIFICANCE: Zika-related microcephaly was associated with high risk of early epilepsy. Seizures typically began after the third month of life, usually as infantile spasms, with atypical electroencephalographic abnormalities. The seizure control rate was low. The onset of seizures in the second year was less frequent and, when it occurred, presented as focal epilepsy.
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