ArticleeLife2020
EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
What it found
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Ubiquitin and ubiquitin-like modifications in the endoplasmic reticulum stress response.The FEBS journal · 2026Review
- Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER.iScience · 2026Article
- Glycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation.Genome biology · 2026Article
- Therapeutic Targets for Lung Squamous Cell Carcinoma: Proteome-Wide Mendelian Randomization and Potential Drug Prediction.The clinical respiratory journal · 2026Article
- Loss of SEL1L or Hrd1 increases intrinsic LOX levels in HEK293 cells independently of proteasomal degradation.Molecular biology reports · 2026Article
- N-glycan-dependent protein maturation and quality control in the ER.Nature reviews. Molecular cell biology · 2025Review
- Novel Insights into Schizophrenia Treatment: Comprehensive Analysis Unveiling FGFR1 as a Promising Druggable Gene.Molecular neurobiology · 2025Article
- Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase.Nature structural & molecular biology · 2025Article
- UGGT1-mediated reglucosylation ofeLife · 2024Article
- Initiation of ERAD by the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase.bioRxiv : the preprint server for biology · 2024Article
- Protein degrons and degradation: Exploring substrate recognition and pathway selection in plants.The Plant cell · 2024Review
- A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α.eLife · 2024Article
- The Essential Functions of Molecular Chaperones and Folding Enzymes in Maintaining Endoplasmic Reticulum Homeostasis.Journal of molecular biology · 2024Review
- Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?Current issues in molecular biology · 2024Review
- Mechanisms of substrate processing during ER-associated protein degradation.Nature reviews. Molecular cell biology · 2023Review
- Expression analysis and functional characterization of thioredoxin domain-containing protein 11.Molecular biology reports · 2022Article
- The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.Nature communications · 2022Article
- Targeting EDEM protects against ER stress and improves development and survival in C. elegans.PLoS genetics · 2022Article
- Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases.Biology · 2022Review
- Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition.Frontiers in molecular biosciences · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Ginto George *Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0003-4804-9594
Satoshi Ninagawa *Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0002-8005-4716
Hirokazu YagiGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0001-9296-0225
Taiki SaitoGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0002-7580-4340
Tokiro IshikawaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0003-1718-6764
Tetsushi SakumaDivision of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.ORCID 0000-0003-0396-1563
Takashi YamamotoDivision of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Koshi ImamiDepartment of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.ORCID 0000-0002-7451-4982
Yasushi IshihamaDepartment of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.ORCID 0000-0001-7714-203X
Koichi KatoGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID 0000-0001-7187-9612
Tetsuya OkadaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0002-2513-1301
Kazutoshi MoriDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID 0000-0001-7378-4019
Kyoto University · JPHiroshima University · JPNagoya City University · JPNational Institutes of Natural Sciences · JP
Funding
Ministry of Education, Culture, Sports, Science, and Technology 17H01432Ministry of Education, Culture, Sports, Science, and Technology 17H06414Ministry of Education, Culture, Sports, Science, and Technology 17H06419Ministry of Education, Culture, Sports, Science, and Technology 18K06110Ministry of Education, Culture, Sports, Science, and Technology 18K06216Ministry of Education, Culture, Sports, Science, and Technology 19K06658
Abstract
Sequential mannose trimming of N-glycan (Man
Indexed as
Endoplasmic Reticulum-Associated Degradationalpha-MannosidaseCarrier ProteinsCatalysisCRISPR-Associated Protein 9CRISPR-Cas SystemsGene EditingGene Knockdown TechniquesGlycoproteinsHCT116 CellsHumansMannoseMannosidasesPolymerase Chain Reactionalpha-MannosidaseCarrier ProteinsCRISPR-Associated Protein 9EDEM2 protein, humanGlycoproteinsMannoseMannosidasesTXNDC11 protein, humancell biologyendoplasmic reticulumglycoproteinhumanmannose trimmingprotein degradationprotein misfolding
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.