ArticleeLife2020
ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
105 citing papers in PubMed, 195 citations in OpenAlex.
- Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability.Molecular therapy. Nucleic acids · 2026Review
- Folding a broken genome: the versatile roles of cohesin in genome maintenance.Nature reviews. Genetics · 2026Review
- Re-establishment of TAD boundary organization during DNA replication.bioRxiv : the preprint server for biology · 2026Article
- Distinct and compensatory roles of STAG1 and STAG2 in post-mitotic genome refolding.Nature communications · 2026Article
- Context-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2.Nature communications · 2026Article
- Cohesin activity accelerates the homology search.bioRxiv : the preprint server for biology · 2026Article
- Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types.Nature structural & molecular biology · 2026Article
- Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells.bioRxiv : the preprint server for biology · 2026Article
- Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption.Molecular cell · 2026Article
- Organization of replicated chromosomes by DNA loops and sister chromatid cohesion.Nature reviews. Molecular cell biology · 2026Review
- PDS5A and TOP2B cooperate for chromatin recruitment via CTCF.bioRxiv : the preprint server for biology · 2026Article
- Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation.Nature genetics · 2026Article
- The physical chemistry of interphase loop extrusion.Cell genomics · 2026Article
- CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells.iScience · 2026Article
- A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding.Science advances · 2026Article
- Altered Cohesin Dynamics During Cellular Differentiation.bioRxiv : the preprint server for biology · 2026Article
- STAG2-truncating variants reveal a mosaic STAG2 inactivation pattern and compensatory mechanisms involving cohesin complex remodeling.iScience · 2025Article
- High-throughputbioRxiv : the preprint server for biology · 2025Article
- CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igκ repertoire.Nature communications · 2025Article
- Automated FRAP microscopy for high-throughput analysis of protein dynamics in chromatin organization and transcription.FEBS open bio · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 3 countries.
Gordana WutzResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.ORCID 0000-0002-6842-0795
Rene LadurnerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Brian Glenn St HilaireThe Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Roman R StocsitsResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Kota NagasakaResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.ORCID 0000-0003-0765-638X
Benoit PignardResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Adrian SanbornThe Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Wen TangResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Csilla VárnaiNuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Miroslav P IvanovResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.ORCID 0000-0001-9352-0969
Stefan SchoenfelderNuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.ORCID 0000-0002-3200-8133
Petra van der LelijResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Xingfan HuangThe Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Gerhard DürnbergerInstitute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.
Elisabeth RoitingerInstitute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.
Karl MechtlerResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Iain Finley DavidsonResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Peter FraserNuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Erez Lieberman-AidenThe Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Jan-Michael PetersResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.ORCID 0000-0003-2820-3195
Research Institute of Molecular Pathology · ATBaylor College of Medicine · USInstitute of Molecular Biotechnology · ATBabraham Institute · GBBroad Institute · USFlorida State University · US
Funding
GENOME WIDE MAPPING OF LOOPS USING IN SITU HI-CUM1HG009375 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2017 to 2021
$4.7MSupplement - Beyond pairwise DNA contacts: exploring higher-order genome structure using proximity ligationU01HL130010 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2015 to 2019
$2.3MAustrian Research Promotion Agency FFG-852936Austrian Science Fund SFB F34Austrian Science Fund by ERA-CAPS 3686Biotechnology and Biological Sciences Research Council BB/J004480/1EMBO ALTF 1335-2016European Research Council 340152 DEVOCHROMOH2020 European Research Council 693949Horizon 2020 Framework Programme EPIC-XS 823839Human Frontier Science Program LT001527/2017Human Frontier Science Program RGP0057/2018Medical Research Council MR/T016787/1National Science Foundation PHY-1427654NHGRI NIH HHS UM1 HG009375NHLBI NIH HHS U01 HL130010NIH Clinical Center 5U01HL130010-05NIH Clinical Center 5UM1HG009375-03Österreichische Forschungsförderungsgesellschaft FFG-852936Seventh Framework Programme FP7/2007-2013 241548The Austrian Science Fund SFB F34The Austrian Science Fund Z196-B20The European community's Seventh Frame- work Programme FP7/2007-2013 241548Vienna Science and Technology Fund WWTF LS09-13
Abstract
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes
Indexed as
AcetylationAcetyltransferasesCarrier ProteinsCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsComputer SimulationG1 PhaseGenome, HumanHumansNuclear ProteinsProtein BindingProto-Oncogene ProteinsAcetyltransferasesCarrier ProteinsCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsCTCF protein, humanESCO1 protein, humanNuclear ProteinsProto-Oncogene ProteinsWAPL protein, humancell biologychromatin structurechromosomescohesinCTCFgene expressiongenome organizationhumanloopsTADs
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.