ArticleeLife2020
Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- A temporal differentiation program after birth delineates γδ T cell immunity.Science advances · 2026Article
- Article
- GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment.Frontiers in immunology · 2026Article
- RasGRP1 signaling is required for Vγ2+ thymocyte c-Maf expression and γδT17 lineage programming.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Aqueous extracts ofFrontiers in pharmacology · 2025Article
- Review
- Local Enrichment with Convergence of Enriched T-Cell Clones Are Hallmarks of Effective Peptide Vaccination against B16 Melanoma.Vaccines · 2024Article
- Exploring the association between rosacea and acne by integrated bioinformatics analysis.Scientific reports · 2024Article
- High-parameter immunophenotyping reveals distinct immune cell profiles in pruritic dogs and cats.Frontiers in veterinary science · 2024Article
- Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies.Veterinary medicine (Auckland, N.Z.) · 2024Review
- Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human.Frontiers in medicine · 2024Review
- The Roles of Innate Immune Cells in Atopic Dermatitis.Journal of innate immunity · 2024Review
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- Article
- Dietary Cholesterol Metabolite Regulation of Tissue Immune Cell Development and Function.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma-Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with Skin-Homing Properties and Epigenetic Implications Mediated by miRNA.International journal of molecular sciences · 2022Article
- Skin γδ T Cells and Their Function in Wound Healing.Frontiers in immunology · 2022Review
- γδ T cells in tissue physiology and surveillance.Nature reviews. Immunology · 2021Review
- Skin Resident γδ T Cell Function and Regulation in Wound Repair.International journal of molecular sciences · 2020Review
- Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.The Yale journal of biology and medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Atopic Dermatitis (AD) is a T cell-mediated chronic skin disease and is associated with altered skin barrier integrity. Infants with mutations in genes involved in tissue barrier fitness are predisposed towards inflammatory diseases, but most do not develop or sustain the diseases, suggesting that there exist regulatory immune mechanisms to prevent aberrant inflammation. The absence of one single murine dermal cell type, the innate neonatal-derived IL-17 producing γδ T (Tγδ17) cells, from birth resulted in spontaneous, highly penetrant AD with many of the major hallmarks of human AD. In Tγδ17 cell-deficient mice, basal keratinocyte transcriptome was altered months in advance of AD induction. Tγδ17 cells respond to skin commensal bacteria and the fulminant disease in their absence was driven by skin commensal bacteria dysbiosis. AD in this model was characterized by highly expanded dermal αβ T clonotypes that produce the type three cytokines, IL-17 and IL-22. These results demonstrate that neonatal Tγδ17 cells are innate skin regulatory T cells that are critical for skin homeostasis, and that IL-17 has dual homeostatic and inflammatory function in the skin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.