ArticleEuropean journal of neurology2020
Ventilation time and prognosis after stroke thrombectomy: the shorter, the better!
Article in European journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05847309 (Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. A Prospective, Randomized Comparison Between Early vs Delayed Extubation), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. A Prospective, Randomized Comparison Between Early vs Delayed Extubation
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Advances in stroke-associated pneumonia in the era of revascularization therapy.Chinese medical journal · 2026Review
- Effect of extubation timing on prognosis in patients with acute stroke undergoing mechanical thrombectomy under general anesthesia: A retrospective study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Observational
- Anesthetic Strategy, Functional Outcomes, and Infectious Complications After Mechanical Thrombectomy for Acute Ischemic Stroke.Journal of clinical medicine · 2026Article
- Article
- Perioperative Determinants of Functional Outcome and Mortality After Mechanical Thrombectomy Under General Anesthesia.Journal of clinical medicine · 2026Article
- Association of Blood-Based Biomarkers and Malignant Infarction in Severe Anterior Circulation Ischemic Stroke.Brain and behavior · 2026Article
- COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS) to improve favorable neurological outcome: a matched-pair analysis.European stroke journal · 2026Article
- Intubation duration after general anesthesia for thrombectomy in acute ischemic stroke: a cohort study.Frontiers in neurology · 2026Article
- Risk factors of stroke-associated pneumonia in patients with acute ischemic stroke treated by endovascular thrombectomy.BMC neurology · 2025Article
- Clinical perspective in relation to age in patients treated with thrombectomy for anterior circulation stroke in a stroke center in Colombia.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Observational
- A superior tool for predicting sepsis in SAH patients: The nomogram outperforms SOFA score.PloS one · 2025Article
- Article
- Nomogram to predict ventilator-associated pneumonia in large vessel occlusion stroke after endovascular treatment: a retrospective study.Frontiers in neurology · 2024Article
- Development and verification of a nomogram for predicting short-term mortality in elderly ischemic stroke populations.Scientific reports · 2023Article
- Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Effect of differences in extubation timing on postoperative pneumonia following meningioma resection: a retrospective cohort study.BMC anesthesiology · 2022Article
- Impact on functional outcome of an adaptive Stroke Unit based system of care for patients undergoing endovascular treatment during pandemic times.European stroke journal · 2022Article
- Predicting Poststroke Pneumonia in Patients With Anterior Large Vessel Occlusion: A Prospective, Population-Based Stroke Registry Analysis.Frontiers in neurology · 2022Article
- Sepsis in Patients With Large Vessel Occlusion Stroke-Clinical Characteristics and Outcome.Frontiers in neurology · 2022Article
- Acute and Chronic Kidney Dysfunction and Outcome After Stroke Thrombectomy.Translational stroke research · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe aim was to investigate the clinical impact of the duration of artificial ventilation in stroke patients receiving mechanical thrombectomy (MT) under general anaesthesia.
methodsAll consecutive ischaemic stroke patients who had been treated at our centre with MT for anterior circulation large vessel occlusion under general anaesthesia were identified over an 8-year period. Ventilation time was analysed as a continuous variable and patients were grouped into extubation within 6 h ('early'), 6-24 h ('delayed') and >24 h ('late'). Favourable outcome was defined as modified Rankin Scale scores of 0-2 at 3 months post-stroke. Pneumonia rate and reasons for prolonged ventilation were also assessed.
resultsAmongst 447 MT patients (mean age 69.1 ± 13.3 years, 50.1% female), the median ventilation time was 3 h. 188 (42.6%) patients had a favourable 3-month outcome, which correlated with shorter ventilation time (Spearman's rho 0.39, P < 0.001). In patients extubated within 24 h, early compared to delayed extubation was associated with improved outcome (odds ratio 2.40, 95% confidence interval 1.53-3.76, P < 0.001). This was confirmed in multivariable analysis (P = 0.01). A longer ventilation time was associated with a higher rate of pneumonia during neurointensive care unit/stroke unit stay (early/delayed/late extubation: 9.6%/20.6%/27.7%, P < 0.01). Whilst stroke-associated complications represented the most common reasons for late extubation (>24 h), delayed extubation (6-24 h) was associated with admission outside of core working hours (P < 0.001).
conclusionsProlonged ventilation time after stroke thrombectomy independently predicts unfavourable outcome at 3 months and is associated with increased pneumonia rates. Therefore, extubation should be performed as early as safely possible.
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