Evidence map›Paper›PMID 32065339›Full record

ArticleJournal of muscle research and cell motility2020

Novel insights into cerebral palsy.

Else Marie Bartels, Lise Korbo, Adrian P Harrison

Registry-linked trialAbstract readNews
PubMed Publisher
In one paragraph

Article in Journal of muscle research and cell motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07173647 (Pediatric Endurance and Limb Strengthening Program With and Without Electrical Muscle Stimulation Among Children With Cerebral Palsy), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07173647 nacompletednot on this mapstarted 2024, after this paper: background citation

Pediatric Endurance and Limb Strengthening Program With and Without Electrical Muscle Stimulation Among Children With Cerebral Palsy

TypeinterventionalSponsorUniversity of LahoreRan2024 to 2025Enrolled26ConditionsCerebral Palsy (CP)ArmsPEDAL Program with Electrical Muscle Stimulation, PEDAL Program without Electrical Muscle Stimulation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Systematic review and network meta-analysis of robot-assisted gait training on lower limb function in patients with cerebral palsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Else Marie BartelsDepartment of Neurology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Nilsine Nielsens Vej 7, indgang 3, 2. sal, 2400, København, NV, Denmark. Else.Marie.Bartels@RegionH.dk.ORCID 0000-0001-9302-9678
Lise KorboDepartment of Neurology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Nilsine Nielsens Vej 7, indgang 3, 2. sal, 2400, København, NV, Denmark.
Adrian P HarrisonPAS (Physiology), Faculty of Health & Medical Sciences, Copenhagen University, Frederiksberg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. CP affects about 1 in 500 neonates. CP shows clinical features which evolve with age, and these may over time lead to deterioration of motor function although the lesion to the developing brain is non-progressive. The underlying causes for CP remain unclear. Based on recent research we are able to give a physiological explanation on the appearance and development of the condition. The damage to the central nervous system causes a change in collagen structure, with a higher level of deposition of collagen around the muscles, increasing throughout life. Assuming this premise is correct, the question is, will it by any treatment be possible to delay or prevent this collagen accumulation in the CP muscles, thereby giving CP patients a better prognosis in the future.

Indexed as

Cerebral PalsyHumansCerebral palsyCollagenMuscle

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.