ArticleGeroScience2020
n-3 polyunsaturated fatty acids as modulators of thermogenesis in Ames dwarf mice.
Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Lipids, commonly split into saturated and mono- and polyunsaturated fatty acids, are key constituents of all biological membranes, and their exact proportions in different tissues were previously shown to be related to lifespan in mammals. As a mechanism, it was put forward that long-chain and highly unsaturated n-3 fatty acids may act as "pacemakers" in membranes while the n-6 fatty acid class may act as a counterbalance. Previously, long-lived Ames dwarf mice (Prop1 df/df) were found to have lower n-3 fatty acids and higher n-6 throughout their tissues. We exposed 32 adult (8 months old) Ames dwarf mice to three isocaloric diets differing in their fatty acid composition (saturated vs. rich in n-3 and n-6) for 2 months while measuring their body masses, subcutaneous body temperatures and finally membrane fatty acid profiles. Prominently, we found that individuals from all three groups quickly increased their body masses by ca. 20% and had 0.45 °C higher subcutaneous body temperatures than at baseline (F
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Registered trials
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