Evidence map›Paper›PMID 32065256›Full record

ArticleBrain structure & function2020

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors.

Rachel P Tillage, Natale R Sciolino, Nicholas W Plummer, Daniel Lustberg, L Cameron Liles, Madeline Hsiang, Jeanne M Powell, Kathleen G Smith, Patricia Jensen, David Weinshenker

Open access · greenAbstract read
In one paragraph

Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  13. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
  14. Article
  15. Article
  16. A knock-in allele of Hand2 expressing Dre recombinase.Genesis (New York, N.Y. : 2000) · 2024
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rachel P TillageDepartment of Human Genetics, Emory University School of Medicine, Whitehead 301, 615 Michael St., Atlanta, GA, 30322, USA.
Natale R SciolinoNeurobiology Laboratory, Developmental Neurobiology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Nicholas W PlummerNeurobiology Laboratory, Developmental Neurobiology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Daniel LustbergDepartment of Human Genetics, Emory University School of Medicine, Whitehead 301, 615 Michael St., Atlanta, GA, 30322, USA.
L Cameron LilesDepartment of Human Genetics, Emory University School of Medicine, Whitehead 301, 615 Michael St., Atlanta, GA, 30322, USA.
Madeline HsiangNeurobiology Laboratory, Developmental Neurobiology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Jeanne M PowellNeurobiology Laboratory, Developmental Neurobiology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Kathleen G SmithNeurobiology Laboratory, Developmental Neurobiology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Patricia JensenNeurobiology Laboratory, Developmental Neurobiology Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA. patricia.jensen@nih.gov.
David WeinshenkerDepartment of Human Genetics, Emory University School of Medicine, Whitehead 301, 615 Michael St., Atlanta, GA, 30322, USA. dweinsh@emory.edu.
National Institute of Environmental Health Sciences · USEmory University · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Central Noradrenergic Neuron Subtype Development and FunctionZIAES102805 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JENSEN, PATRICIA · 2010 to 2025
$33.9M
Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Mechanisms of cocaine hypersensitivity following chronic DBH inhibition 5R01DA038453-02 Diversity SupplementR01DA038453 · NIDA · EMORY UNIVERSITY · PI PALADINI, CARLOS ANTONIO, WEINSHENKER, DAVID · 2015 to 2019
$1.8M
Consequences of Locus Coeruleus Activation in a Rat Model of Alzheimer's DiseaseRF1AG047667 · NIA · EMORY UNIVERSITY · PI WEINSHENKER, DAVID · 2014 to 2014
$1.7M
Defining locus coeruleus-norepinephrine (LC-NE) circuits in feedingR00DK119586 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI SCIOLINO, NATALE R · 2021 to 2023
$730k
The role of locus coeruleus hyperactivity and galanin in depressive behaviorF31MH116622 · NIMH · EMORY UNIVERSITY · PI TILLAGE, RACHEL CATHERINE PEARCY · 2018 to 2020
$135k
Intramural NIH HHS ZIA ES102805NCATS NIH HHS UL1 TR002378NIA NIH HHS AG047667NIA NIH HHS RF1 AG047667NIDA NIH HHS DA038453NIDA NIH HHS R01 DA038453NIDDK NIH HHS K99 DK119586NIDDK NIH HHS R00 DK119586NIEHS NIH HHS ES102805NIMH NIH HHS F31 MH116622NIMH NIH HHS MH116622NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Accumulating evidence indicates that disruption of galanin signaling is associated with neuropsychiatric disease, but the precise functions of this neuropeptide remain largely unresolved due to lack of tools for experimentally disrupting its transmission in a cell type-specific manner. To examine the function of galanin in the noradrenergic system, we generated and crossed two novel knock-in mouse lines to create animals lacking galanin specifically in noradrenergic neurons (Gal

Indexed as

Adaptation, PsychologicalAdrenergic NeuronsAnimalsBrainFemaleGalaninGene Knock-In TechniquesHippocampusMaleMice, KnockoutPonsPrefrontal CortexGalaningalanin protein, mouseConditional knockoutGalaninLocus coeruleusMiceNorepinephrine

Identifiers

PMID32065256
PMCPMC7238760
OpenAlexW3006791058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.