ArticleChemical communications (Cambridge, England)2020
The methionase chain reaction: an enzyme-based autocatalytic amplification system for the detection of thiols.
Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Activation of enzymatic catalysis via nucleic acid hybridization affords synergistic coupling of specificity, potency, and signal amplification.Nature communications · 2025Article
- A self-immolative linker that releases thiols detects penicillin amidase and nitroreductase with high sensitivityChemical communications (Cambridge, England) · 2022Article
- Exponential amplification by redox cross-catalysis and unmasking of doubly protected molecular probes.Chemical science · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We present an autocatalytic system for the detection and amplification of thiols termed the Methionase Chain Reaction (MCR). MCR is based on the reversible modification of the thiol producing enzyme Methionine Gamma-Lyase (MGL). MCR was able to amplify the concentration of thiols by a factor of 560 and was able to visually detect thiols at concentrations as low as 50 nM.
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Registered trials
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