ArticleEmerging microbes & infections2020
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
Article in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 955 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome in Referral Hospitals in Indonesia
A Multi-center, Randomized, Open-label, Controlled Trial to Evaluate the Efficacy and Tolerability of Hydroxychloroquine (HCQ) in Adult Patients With Mild to Moderate Coronavirus Disease (COVID-19) Compared to Standard of Care Treatment
The Relationship Between Lab Finding and COVID-19 Severity: Multicenter Study
Evaluation of The Efficacy of Triazavirin Versus Oseltamivir in Egyptian Patients Infected With Coronavirus Disease 2019 (COVID-19)
Who cites it
955 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,898 citations in OpenAlex.
- Antibody tests for identification of current and past infection with SARS-CoV-2.The Cochrane database of systematic reviews · 2022Pooled it
- High prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort study.Gastroenterologia y hepatologia · 2022Pooled it
- Case fatality rate of the adult in-patients with COVID-19 and digestive system tumors: A systematic review and meta-analysis.Medicine · 2022Pooled it
- SARS-CoV-2 shedding sources in wastewater and implications for wastewater-based epidemiology.Journal of hazardous materials · 2022Pooled it
- The importance of fecal nucleic acid detection in patients with coronavirus disease (COVID-19): A systematic review and meta-analysis.Journal of medical virology · 2022Pooled it
- Supervised and weakly supervised deep learning models for COVID-19 CT diagnosis: A systematic review.Computer methods and programs in biomedicine · 2022Pooled it
- Mesenteric ischemia in patients with COVID-19: an updated systematic review of abdominal CT findings in 75 patients.Abdominal radiology (New York) · 2022Pooled it
- Clinical manifestations, treatment options, and comorbidities in COVID-19 relapse patients: A systematic review.Journal of clinical laboratory analysis · 2022Pooled it
- Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostic Tests for Border Screening During the Very Early Phase of Coronavirus Disease 2019 Pandemic: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Rapid diagnosis of COVID-19 in the first year of the pandemic: A systematic review.International immunopharmacology · 2021Pooled it
- Probiotic Therapy of Gastrointestinal Symptoms During COVID-19 Infection: A Randomized, Double-Blind, Placebo-Controlled, Remote Study.Nutrients · 2024Trial
- Gut Microbiota-Derived Bacterial Extracellular Vesicles in COVID-19: Their Signature and Immunological Impact.Journal of extracellular vesicles · 2026Article
- Effect of SARS-CoV-2 infection on pregnant outcomes after embryo transfer: a multicenter retrospective study.BMC pregnancy and childbirth · 2026Article
- A retrospective multicentre review of the efficiency of the novel coronavirus emergency operating theatre.Singapore medical journal · 2026Article
- COVID-19 disease: novel clinical manifestations and therapeutic exploration.Archives of medical science : AMS · 2026Article
- Remdesivir safety and clinical outcomes in pediatric COVID-19: a retrospective study.BMC infectious diseases · 2025Article
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- Impact of COVID-19 on the Gut Microbiome: A Review.Cureus · 2025Review
- Review
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895 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.