Evidence map›Paper›PMID 32065053›Full record

ReviewPeritoneal dialysis international : journal of the International Society for Peritoneal Dialysis2020

Vancomycin in peritoneal dialysis: Clinical pharmacology considerations in therapy.

Edwin Lam, Yi Ting Kayla Lien, Water K Kraft, Beth Piraino, Valvanera Vozmediano, Stephan Schmidt, Jingjing Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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  12. The Correlation between Serum Sclerostin Level and Arterial Stiffness in Peritoneal Dialysis Patients.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Edwin LamDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.
Yi Ting Kayla LienCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA.
Water K KraftDepartment of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.
Beth PirainoRenal Electrolyte Division, School of Medicine, University of Pittsburgh, PA, USA.
Valvanera VozmedianoCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA.
Stephan SchmidtCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA.
Jingjing ZhangDivision of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Thomas Jefferson University · USUniversity of Florida · USUniversity of Pittsburgh · US

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

Intraperitoneal vancomycin is the first-line therapy in the management of peritoneal dialysis (PD)-related peritonitis. However, due to the paucity of data, vancomycin dosing for peritonitis in patients on automated peritoneal dialysis (APD) is empiric and based on clinical experience rather than evidence. Studies in continuous ambulatory peritoneal dialysis (CAPD) patients have been used to provide guidelines for dosing and are often extrapolated for APD use, but it is unclear whether this is appropriate. This review summarizes the available pharmacokinetic data used to inform optimal dosing in patients on CAPD or APD. The determinants of vancomycin disposition and pharmacodynamic effects are critically summarized, knowledge gaps explored, and a vancomycin dosing algorithm in PD patients is proposed.

Indexed as

Peritoneal DialysisAnti-Bacterial AgentsHumansKidney Failure, ChronicPeritonitisVancomycinAnti-Bacterial AgentsVancomycinAnuriaautomated peritoneal dialysiscontinuous ambulatory peritoneal dialysisperitonitispharmacodynamicspharmacokineticsresidual kidney function

Identifiers

PMID32065053
PMCPMC9847573
OpenAlexW3006419502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.