ArticleRespirology (Carlton, Vic.)2020
Reference values for high attenuation areas on chest CT in a healthy, never-smoker, multi-ethnic sample: The MESA study.
Article in Respirology (Carlton, Vic.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Current perspectives on interstitial lung abnormalities.The Korean journal of internal medicine · 2025Review
- Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2024Article
- Quantitative Analysis for Lung Disease on Thin-Section CT.Diagnostics (Basel, Switzerland) · 2023Review
- Quantitative Computed Tomography: What Clinical Questions Can it Answer in Chronic Lung Disease?Lung · 2022Review
- Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities.American journal of respiratory and critical care medicine · 2022Article
- Associations of D-Dimer with Computed Tomographic Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study.Annals of the American Thoracic Society · 2021Article
- Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults: The MESA Cohort Study.Chest · 2021Article
- Associations of ω-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults.American journal of epidemiology · 2021Article
- Interstitial lung abnormalities - current knowledge and future directions.European clinical respiratory journal · 2021Review
- Article
Corrections and comments
- Commented on by
- Erratum issuedCORRIGENDUM.2021
Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveNormative values for HAA-a quantitative, CT-based measure of subclinical ILD-in healthy adults are needed to improve interpretability in clinical and research settings.
methodsHAA was measured on full-lung CT in 3110 participants in the MESA study. Clinical prediction models were developed using a healthy never-smoker subset with normal spirometry (n = 696). RMSE on cross-validation was used as the primary criterion for model selection. Parametric and non-parametric methods were considered. z-Scores were calculated for the entire study sample. Associations between z-scores and several ILD features were estimated.
resultsIn the healthy never-smoker subset, the mean age was 69 years with a range of 54-93 years. The median HAA was 4.3% with a range of 2.7-17.8%. Linear regression had better predictive performance than other methods. The final model included race, height, weight, age and sex. The standard error of the estimate was 1.62 with a cross-validated RMSE of 1.64 and an adjusted R
conclusionWe present a reference equation and z-scores to define expected values of HAA on full-lung CT to aid HAA interpretation in middle-aged and older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.