ArticleThe European journal of neuroscience2021
Acute ethanol exposure rapidly alters cerebellar and cortical microglial physiology.
Article in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Application to developmental toxicity testing of a novel method for whole-brain imaging of microglia in zebrafish.Current research in toxicology · 2026Article
- The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex.Brain, behavior, and immunity · 2025Article
- Cranial irradiation disrupts homeostatic microglial dynamic behavior.Journal of neuroinflammation · 2024Article
- Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum.Cells · 2024Article
- Cortical microglia dynamics are conserved during voluntary wheel running.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence.Frontiers in neuroscience · 2023Article
- Alcohol and the Brain.Nutrients · 2021Review
- Dynamics of microglia and dendritic spines in early adolescent cortex after developmental alcohol exposure.Developmental neurobiology · 2021Article
- Special issue editorial: Glial plasticity in health and disease.The European journal of neuroscience · 2021Article
- Caffeine consumption attenuates ethanol-induced inflammation through the regulation of adenosinergic receptors in the UChB rats cerebellum.Toxicology research · 2021Article
- Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders.Journal of neuroscience research · 2021Article
- Little cells of the little brain: microglia in cerebellar development and function.Trends in neurosciences · 2021Review
- Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6.Neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol use is highly prevalent in modern society and ramifications of alcohol abuse pose a large public health concern. Previous work investigating the effects of alcohol exposure on the brain has implicated microglia, the resident immune cells of the central nervous system (CNS), as critical participants in the brain's response to chronic and developmental ethanol (EtOH) exposure. As rapid sensors of their environment, microglia also have the capacity to rapidly respond to alcohol administration and to contribute to acute effects of alcohol on the brain; however, their acute responses have not been assessed. Here, for the first time, we have examined the acute response of microglia to alcohol intoxication in vivo utilizing two-photon microscopy to assess the dynamics of these motile cells in both visual cortex and the cerebellum of mice. We found that microglia respond rapidly to EtOH exposure with fast changes in morphology, motility, parenchyma surveillance, and injury response. However, regional differences between the responses of cerebellar and cortical microglial populations indicate that subtle differences in microglial physiology may alter their vulnerability to acute alcohol intoxication. Our findings suggest that the longer-term effects of repeated EtOH exposure on microglia may result from repeat acute alterations in microglial physiology by single exposure to alcohol which rapidly alter behavior in specific microglial populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.