ArticleScience advances2020
Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
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Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
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- Integrating network toxicology, machine learning, and molecular dynamics simulations to reveal tanshinone iia's dual mechanisms in TNBC and doxorubicin-induced cardiotoxicity.Scientific reports · 2026Article
- Astragaloside IV inhibits the progression of hypertensive heart disease via the RXRA/PPARG/SIRT3 axis.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Inhibition, But Not Depletion, of Erk Signaling Ameliorates Anthracycline-Induced Cardiotoxicity in Zebrafish.JACC. CardioOncology · 2025Article
- Tight Regulation of Erk Activity Protects From Anthracycline-Induced Cardiotoxicity.JACC. CardioOncology · 2025Article
- The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis.Nature communications · 2025Article
- Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy.Disease models & mechanisms · 2023Article
- miScience · 2023Article
- Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play.Frontiers in cardiovascular medicine · 2023Review
- Kidney transcriptome and cystic kidney disease genes in zebrafish.Frontiers in physiology · 2023Article
- Synergistic Effects of Ginsenoside Rb3 and Ferruginol in Ischemia-Induced Myocardial Infarction.International journal of molecular sciences · 2022Article
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- Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.Nature communications · 2022Article
- Modeling Susceptibility to Cardiotoxicity in Cancer Therapy Using Human iPSC-Derived Cardiac Cells and Systems Biology.Heart failure clinics · 2022Review
- Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity.Oxidative medicine and cellular longevity · 2022Review
- All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity.PloS one · 2022Article
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- A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models.Bio-protocol · 2021Article
- Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease.International journal of molecular sciences · 2021Review
- Disruption ofBioMed research international · 2021Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Xiao MaDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9940-8468
Ping ZhuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Yonghe DingDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Hong ZhangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4116-7347
Qi QiuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7756-7134
Alexey V DvornikovDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-1514-4747
Zheng WangDepartment of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6002-5299
Maengjo KimDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Yong WangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Matthew LowerisonDepartment of Urology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-1125-4554
Yue YuDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Nadine NortonDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Joerg HerrmannDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Stephen C EkkerDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-0726-4212
Tzung K HsiaiSchool of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Xueying LinDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Xiaolei XuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4928-3422
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · USBeijing University of Chinese Medicine · CNCapital Medical University · CNCentral South University · CNUniversity of California, Los Angeles · US
Funding
Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4MZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4MInstitutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9MSystematic Vertebrate Functional GenomicsR01GM063904 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EKKER, STEPHEN CARL · 2001 to 2025
$10.7MGenetic Studies of Sarcomere-based Cardiac Diseases (Diversity Supplement)R01HL081753 · NHLBI · MAYO CLINIC ROCHESTER · PI XU, XIAOLEI · 2005 to 2025
$7.8MEpicardial remodeling in cardiomyopathy and cardiac agingR01HL107304 · NHLBI · MAYO CLINIC ROCHESTER · PI Xiaolei Xu · 2011 to 2026
$6.6MInternational Zebrafish Mutagenic Protein TrapR01HG006431 · NHGRI · MAYO CLINIC ROCHESTER · PI EKKER, STEPHEN CARL · 2011 to 2016
$3.3MMicro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1MSystematic Vertebrate Functional GenomicsR56GM063904 · NIGMS · MAYO CLINIC ROCHESTER · PI EKKER, STEPHEN CARL · 2009 to 2010
$611kNCATS NIH HHS KL2 TR002379NCATS NIH HHS UL1 TR002377NCRR NIH HHS M01 RR000585NHGRI NIH HHS R01 HG006431NHLBI NIH HHS R01 HL081753NHLBI NIH HHS R01 HL107304NHLBI NIH HHS R01 HL111437NIGMS NIH HHS R01 GM063904NIGMS NIH HHS R56 GM063904
Abstract
To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor screening strategy in zebrafish. Here, we report the molecular and cellular nature of
Indexed as
AnimalsBexaroteneCardiotonic AgentsCardiotoxicityDisease Models, AnimalEndothelial CellsHeartHumansIsotretinoinMyocardiumNeoplasmsPericardiumRetinoid X Receptor alphaZebrafishZonula Occludens-1 ProteinBexaroteneCardiotonic AgentsIsotretinoinRetinoid X Receptor alphaRXRA protein, humanZonula Occludens-1 Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.