ArticleFrontiers in oncology2019
Genetically Determined Height and Risk of Non-hodgkin Lymphoma.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis.Immunogenetics · 2026Pooled it
- Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas.World journal of gastroenterology · 2023Review
- Etiology of non-Hodgkin lymphoma: A review from epidemiologic studies.Journal of the National Cancer Center · 2022Review
- Body size and risk of non-Hodgkin lymphoma by subtype: A pooled analysis from six prospective cohorts in the United States.British journal of haematology · 2022Article
- Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin's Lymphomas from Genome-Wide Association Studies.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
79 authors at 20 institutions in 13 countries.
Amy MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Eleanor KaneDepartment of Health Sciences, University of York, York, United Kingdom.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Orestis A PanagiotouDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, United States.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, GA, United States.
Alain MonnereauEpidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.
Nicole Wong DooCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Christine F SkibolaDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, United States.
Susan L SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, United States.
Gilles SallesDepartment of Hematology, Hospices Civils de Lyon, Lyon, France.
Nicola J CampDivision of Hematology and Hematologic Malignancies, Department of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United States.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States.
Alexandra NietersCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg im Breisgau, Germany.
Roel C H VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Joseph VijaiClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Karin E SmedbyDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Yawei ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, United States.
Claire M VajdicCentre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia.
Wendy CozenDepartment of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
John J SpinelliCancer Control Research, BC Cancer, Vancouver, BC, Canada.
Henrik HjalgrimDivision of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Graham G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States.
Jacqueline ClavelEpidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.
Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, United States.
Mark P PurdueOntario Health Study, Toronto, ON, Canada.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Giovanni M FerriInterdisciplinary Department of Medicine, University of Bari, Bari, Italy.
Thomas M HabermannDivision of General Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United States.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Yolanda BenaventeCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Simonetta BisanziRegional Cancer Prevention Laboratory, Oncological Network, Prevention and Research Institute (ISPRO), Florence, Italy.
Paolo BoffettaThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Paul BrennanInternational Agency for Research on Cancer (IARC), Lyon, France.
Angela R Brooks-WilsonGenome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center, Heidelberg, Germany.
Lucia CondeBill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, United Kingdom.
David G CoxINSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France.
Karen CurtinDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czechia.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA, United States.
Hervé GhesquièresEquipe Experimental and Clinical Models of Lymphomagenesis, Cancer Research Center of Lyon, Institut National de Santé et de la Recherche Médicale UMR1052 Pierre Benite, Lyon, France.
Martha GlennDepartment of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States.
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, United States.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Mark LiebowDivision of General Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, United States.
Marc MaynadieINSERM U1231, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, France.
James McKayInternational Agency for Research on Cancer (IARC), Lyon, France.
Mads MelbyeDivision of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Lucia MiligiEnvironmental and Occupational Epidemiology Unit, Oncological Network, Prevention and Research Institute (ISPRO), Florence, Italy.
Roger L MilneCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Thierry J MolinaDepartment of Pathology, AP-HP, Necker Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Kenneth OffitClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Marina PadoanCPO-Piemonte and Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Alpa V PatelEpidemiology Research Program, American Cancer Society, Atlanta, GA, United States.
Sara PiroEnvironmental and Occupational Epidemiology Unit, Oncological Network, Prevention and Research Institute (ISPRO), Florence, Italy.
Vignesh RavichandranClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Elio RiboliSchool of Public Health, Imperial College London, London, United Kingdom.
Silvia de SanjoseCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, United States.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, VIC, Australia.
Anthony StainesSchool of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.
Carolyn StewartClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Ruth C TravisCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Tongzhang ZhengDepartment of Epidemiology, Brown School of Public Health, Providence, RI, United States.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, United States.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Division of Cancer Epidemiology and GeneticsMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USAmerican Cancer Society · USCentre international de recherche sur le cancer · FRBrown University · USCancer Council Victoria · AUInserm · FRKarolinska Institutet · SEMayo Clinic · USMayo Clinic in Florida · USPiedmont Reference Center for Epidemiology and Cancer Prevention · ITStatens Serum Institut · DKThe University of Melbourne · AUUniversity of Utah · USAssistance Publique – Hôpitaux de Paris · FRBrigham and Women's Hospital · USCentre de Recherche en Cancérologie de Lyon · FRDublin City University · IEEmory University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER · 2000 to 2019
$77.8MUTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MViral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MThe Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7MMayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2MRESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MCancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MNCATS NIH HHS UL1 TR000135NCCDPHP CDC HHS U58 DP000807NCI NIH HHS HHSN261201000026CNCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS HHSN261201500005CNCI NIH HHS K08 CA134919NCI NIH HHS N01 CO012400NCI NIH HHS N01 PC065064NCI NIH HHS N01 PC067008NCI NIH HHS N01 PC067009NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA062006NCI NIH HHS R01 CA092153NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA134674NCI NIH HHS R01 CA134958NCI NIH HHS R01 CA148690NCI NIH HHS R01 CA149445NCI NIH HHS R01 CA154643NCI NIH HHS R21 CA165923NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA118444NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNIDA NIH HHS HHSN271201600004CNIDA NIH HHS HHSN271201600004INIEHS NIH HHS P30 ES000260World Health Organization 001
Abstract
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17,
Indexed as
chronic lymphocytic leukemiadiffuse large B-cell lymphomafollicular lymphomageneticsheightmarginal zone lymphomanon-Hodgkin lymphomapolygenic risk score
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