ArticleMultiple sclerosis journal - experimental, translational and clinical
Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis.Therapeutic advances in neurological disorders · 2025Review
- The relationship between work difficulties and physical disability, cognitive and social cognitive impairment and subcortical gray matter atrophy in persons with multiple sclerosis.Acta neurologica Belgica · 2024Article
- A Greek Validation Study of the Multiple Sclerosis Work Difficulties Questionnaire-23.Healthcare (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMultiple sclerosis is often associated with unemployment. The contribution of grey matter atrophy to unemployment is unclear.
objectivesTo identify magnetic resonance imaging biomarkers of grey matter and clinical symptoms associated with unemployment in multiple sclerosis patients.
methodsDemographic, clinical data and 1.5 T magnetic resonance imaging scans were collected in 81 patients at the time of inclusion and after 5 and 10 years. Global and tissue-specific volumes were calculated at each time point. Statistical analysis was performed using a mixed linear model.
resultsAt baseline 31 (38%) of the patients were unemployed, at 5-year follow-up 44 (59%) and at 10-year follow-up 34 (81%) were unemployed. The unemployed patients had significantly lower subcortical deep grey matter volume (
conclusionWe found significantly greater atrophy of subcortical deep grey matter and cortical volume at baseline and during follow-up in the unemployed patient group. Atrophy of subcortical deep grey matter showed a stronger association to unemployment than atrophy of cortical volume during the follow-up.
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