ArticleEuropean journal of hospital pharmacy : science and practice2020
Physical stability of an all-in-one parenteral nutrition admixture for preterm infants upon mixing with micronutrients and drugs.
Article in European journal of hospital pharmacy : science and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Physical compatibility of insulin aspart, lidocaine, alprostadil and vancomycin with individualised two-in-one parenteral nutrition used in the neonatal intensive care unit.European journal of hospital pharmacy : science and practice · 2025Article
- Y-Site Compatibility Studies of Parenteral Nutrition and Other Intravenous Medications in Neonatal and Pediatric Patients: A Review of the Literature Evidence.Pharmaceutics · 2024Review
- Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery.Current drug targets · 2024Review
- Negative Outcomes Associated with Medication in Neonates on Parenteral Nutrition Therapy.Pediatric reports · 2023Article
- Honokiol-Loaded Nanoemulsion for Glioblastoma Treatment: Statistical Optimization, Physicochemical Characterization, and an In Vitro Toxicity Assay.Pharmaceutics · 2023Article
- Frequently acquired drugs in neonatal intensive care and their physical compatibility.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Co-administration of drugs with parenteral nutrition in the neonatal intensive care unit-physical compatibility between three components.European journal of pediatrics · 2022Article
- Sodium Valproate Incompatibility with Parenteral Nutrition Admixtures-A Risk to Patient Safety: An In Vitro Evaluation Study.Pharmaceutics · 2022Article
- All-in-One Pediatric Parenteral Nutrition Admixtures with an Extended Shelf Life-Insight in Correlations between Composition and Physicochemical Parameters.Pharmaceutics · 2021Article
- Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins.Antibiotics (Basel, Switzerland) · 2021Article
- Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units.European journal of pediatrics · 2021Article
- Y-Site Physical Compatibility of Numeta G13E with Drugs Frequently Used at Neonatal Intensive Care.Pharmaceutics · 2020Article
- Provision of Standardized All-in-One Parenteral Nutrition (AIO-PN) for Very Preterm Neonates: Evaluation at Room and Cold Temperatures.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The main objective was to investigate Y-site compatibility of intravenous drugs with one standard total parenteral nutrition (TPN) admixture for preterm infants. Since micro-precipitation was observed in the water phase after addition of trace elements, the concentration effect on micro-precipitation formation developed as a sub-goal. Methods: Seven drugs (ampicillin, ceftazidime, fluconazole, fosphenytoin, furosemide, metronidazole and paracetamol) were mixed in three mixing ratios with one preterm TPN admixture. Samples were investigated within 1 hour and again after 4 hours. Precipitation was studied in a lipid-free version called TPN Results: Ampicillin, ceftazidime, fosphenytoin and furosemide led to precipitation after mixing with TPN Conclusions: The micro-precipitate resulting from the addition of trace elements should be investigated further. This study did not provide sufficient evidence to recommend Y-site infusion of the tested drugs and the preterm admixture; however, it might offer some additional support to other compatibility data.
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