Evidence map›Paper›PMID 32064028›Full record

ArticleOxidative medicine and cellular longevity2020

Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model.

Jincheng Zhang, Yang Wang, Minjie Ju, Jieqiong Song, Yijuan Zheng, Shilong Lin, Duming Zhu, Lu Wen, Ming Zhong, Shuming Pan and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Protective effects of Salubrinal against HFrontiers in pharmacology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. The integrated stress response in ischemic diseases.Cell death and differentiation · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jincheng ZhangDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yang WangDepartment of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Minjie JuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Jieqiong SongDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yijuan ZhengDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0002-0163-6401
Shilong LinDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Duming ZhuDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Lu WenDepartment of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-8704-314X
Ming ZhongDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0002-5578-5277
Shuming PanDepartment of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-6922-5545
Guangtian YangDepartment of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Sun Yat-sen University · CNShanghai Jiao Tong University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac arrest (CA) yields poor neurological outcomes. Salubrinal (Sal), an endoplasmic reticulum (ER) stress inhibitor, has been shown to have neuroprotective effects in both in vivo and in vitro brain injury models. This study investigated the neuroprotective mechanisms of Sal in postresuscitation brain damage in a rodent model of CA. In the present study, rats were subjected to 6 min of CA and then successfully resuscitated. Either Sal (1 mg/kg) or vehicle (DMSO) was injected blindly 30 min before the induction of CA. Neurological status was assessed 24 h after CA, and the cortex was collected for analysis. As a result, we observed that, compared with the vehicle-treated animals, the rats pretreated with Sal exhibited markedly improved neurological performance and cortical mitochondrial morphology 24 h after CA. Moreover, Sal pretreatment was associated with the following: (1) upregulation of superoxide dismutase activity and a reduction in maleic dialdehyde content; (2) preserved mitochondrial membrane potential; (3) amelioration of the abnormal distribution of cytochrome C; and (4) an increased Bcl-2/Bax ratio, decreased cleaved caspase 3 upregulation, and enhanced HIF-1

Indexed as

AldehydesAnimalsApoptosisBrain InjuriesCardiopulmonary ResuscitationCaspase 3Cerebellar CortexCinnamatesCytochromes cEndoplasmic Reticulum StressHeart ArrestHypoxia-Inducible Factor 1, alpha SubunitMaleMembrane Potential, MitochondrialMicroscopy, Electron, TransmissionMitochondriaAldehydesBcl2 protein, ratCasp3 protein, ratCaspase 3CinnamatesCytochromes cHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitmalealdehydeNeuroprotective AgentsProto-Oncogene Proteins c-bcl-2salubrinalSod1 protein, ratSuperoxide Dismutase-1Thiourea

Identifiers

PMID32064028
PMCPMC6998743
OpenAlexW3001628597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.