ArticlePakistan journal of medical sciences
Antimicrobial efficacy of 0.8% Hyaluronic Acid and 0.2% Chlorhexidine against
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Comparison of hyaluronic acid, chlorhexidine and persica during SRP.Bioinformation · 2026Article
- Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatment.Pakistan journal of medical sciences · 2025Article
- Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis.European journal of dentistry · 2024Article
- The antimicrobial activity of tea tree oil (PeerJ · 2024Article
- In vitro activity of hyaluronic acid and human serum on periodontal biofilm and periodontal ligament fibroblasts.Clinical oral investigations · 2023Article
- The Effect of Adjunctive Use of Hyaluronic Acid on Prevalence ofPharmaceutics · 2023Review
- High molecular weight hyaluronic acid reduces the growth and biofilm formation of the oral pathogenThe Saudi dental journal · 2023Article
- High Molecular Weight Hyaluronic Acid Reduces the Expression of Virulence Genes fimA, mfa1, hagA, rgpA, and kgp in the Oral PathogenPharmaceutics · 2022Article
- Comparison of the Anti-bacterial Efficacy ofFrontiers in oral health · 2022Article
- Comparison of microbial adhesion and biofilm formation on orthodontic wax materials; an in vitro study.Journal of dental sciences · 2020Article
- Efficacy of hyaluronic acid on the inhibition of periodontal bridging organismsJournal of Indian Society of PeriodontologyArticle
- Hyaluronic acid-based gels for oral application: Comparison ofJournal of oral biology and craniofacial researchArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present in-vitro study was to assess antimicrobial efficacy of 0.8% hyaluronic acid (HA) and 0.2% Chlorhexidine gluconate (CHX) against Porphyromonas gingivalis (P. gingivalis).
methodsThe study was performed between December 2018 and March 2019 at the College of Dentistry at the Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. The P. gingivalis biofilms were formed and grown for 72 hours at 37°C under anaerobic conditions on glass slides coated with human saliva. The slides were individually positioned and exposed to 0.8% HA or 0.2% CHX. Therapeutically, the biofilms were divided into 3 groups as follows: (a) negative group; (b) 0.8% HA group and (c) 0.2% CHX group. P-values less than 0.05 were considered statistically significant.
resultsIn the 0.8% HA group, P. gingivalis CFUs/ml were significantly higher at baseline than at 24- (P<0.05), 48 (P<0.05) and 72 hours (P<0.05) intervals. In the 0.2% CHX group, P. gingivalis CFUs/ml were significantly higher at baseline than at 72 hours interval (P<0.05). In the CHX group, there was no difference in P. gingivalis CFUs/ml between baseline, 24- and 48-hours intervals. At 48- and 72-hours intervals, the P. gingivalis CFUs/ml were significantly higher in the 0.2% CHX group compared with the 0.8% HA group.
conclusionIn-vitro, 0.8% HA is more effective in reducing the P. gingivalis CFUs/ml compared with 0.2% CHX.
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