Evidence map›Paper›PMID 32063920›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2020

Effects of Mlx-8, a phospholipase A

Roberta Tancredi Francesco Dos Santos, Marcelo Florencio Passos Silva, Rafael Marques Porto, Ivo Lebrun, Luís Roberto de Camargo Gonçalves, Isabel de Fátima Correia Batista, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdalla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Pharmacological Screening of Venoms from Five BrazilianInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Roberta Tancredi Francesco Dos SantosLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Marcelo Florencio Passos SilvaLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Rafael Marques PortoLaboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.
Ivo LebrunLaboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.
Luís Roberto de Camargo GonçalvesLaboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil.
Isabel de Fátima Correia BatistaLaboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.
Maria Regina Lopes SandovalLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.
Fernando Maurício Francis AbdallaLaboratory of Pharmacology, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0003-2276-6202
Instituto Butantan · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHere, we described the presence of a neurotoxin with phospholipase A

methodsThe purification, molecular mass determination, partial amino acid sequencing, phospholipase A

resultsThirty-one fractions were collected from HPLC chromatography, and the Mlx-8 toxin was used in this work. The molecular mass of Mlx-8 is 13.628 Da. Edman degradation yielded the following sequence: NLYQFKNMIQCTNTRSWL-DFADYG-CYCGRGGSGT. The Mlx-8 had phospholipase A

conclusionThe results of the present work show, for the first time, that muscarinic receptors are also affected by the Mlx-8 toxin, a muscarinic ligand with phospholipase A

Indexed as

HippocampusInositol phosphateMicrurus lemniscatusMuscarinic receptorsPhopholipase A2

Identifiers

PMID32063920
PMCPMC6986814
OpenAlexW3004238561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.