Evidence map›Paper›PMID 32063901›Full record

ReviewFrontiers in immunology2019

Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?

Nicola Tumino, Paola Vacca, Linda Quatrini, Enrico Munari, Francesca Moretta, Andrea Pelosi, Francesca Romana Mariotti, Lorenzo Moretta

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Epigenetic Dysregulation in Autoimmune and Inflammatory Skin Diseases.Clinical reviews in allergy & immunology · 2022
    Review
  5. Plasticity of NK cells in Cancer.Frontiers in immunology · 2022
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nicola TuminoDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Paola VaccaDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Linda QuatriniDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Enrico MunariDepartment of Pathology, IRCCS Sacro Cuore Don Calabria, Negrar, Italy.
Francesca MorettaDepartment of Laboratory Medicine, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Italy.
Andrea PelosiDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Francesca Romana MariottiDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Lorenzo MorettaDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITBambino Gesù Children's Hospital · ITOspedale Sacro Cuore Don Calabria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) were found to be developmentally related to natural killer (NK) cells. In humans, they are mostly located in "barrier" tissues where they contribute to innate defenses against different pathogens. ILCs are heterogeneous and characterized by a high degree of plasticity. ILC1s are Tbet

Indexed as

HumansImmunity, InnateLymphocytesLymphocyte SubsetsNeoplasmsantitumor immune responsecheckpoint inhibitorsimmunotherapyinnate lymphoid cellsnatural killer cells

Identifiers

PMID32063901
PMCPMC7000626
OpenAlexW3003581116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.