Evidence map›Paper›PMID 32063835›Full record

ReviewFrontiers in neuroscience2020

Oxytocin and Sensory Network Plasticity.

Brandon T Pekarek, Patrick J Hunt, Benjamin R Arenkiel

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Oxytocin, Neural Plasticity, and Social Behavior.Annual review of neuroscience · 2021
    Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brandon T PekarekGenetics and Genomics Program, Baylor College of Medicine, Houston, TX, United States.
Patrick J HuntGenetics and Genomics Program, Baylor College of Medicine, Houston, TX, United States.
Benjamin R ArenkielDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6M
Engineering designer probes for imaging membrane potential: novel parts, architectures, and platformsR01EB027145 · NIBIB · BAYLOR COLLEGE OF MEDICINE · PI ST-PIERRE, FRANCOIS · 2019 to 2022
$2.2M
American Heart Association-American Stroke Association 20PRE35040011NIBIB NIH HHS R01 EB027145NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK109934NINDS NIH HHS R01 NS078294
6 · The paper itself

Abstract

An essential characteristic of nervous systems is their capacity to reshape functional connectivity in response to physiological and environmental cues. Endogenous signals, including neuropeptides, governs nervous system plasticity. Particularly, oxytocin has been recognized for its role in mediating activity-dependent circuit changes. These oxytocin-dependent changes occur at the synaptic level and consequently shape the cellular composition of circuits. Here we discuss recent advances that illustrate how oxytocin functions to reshape neural circuitry in response to environmental changes. Excitingly, recent findings pave the way for promising therapeutic applications of oxytocin to treat neurodevelopmental and neuropsychiatric diseases.

Indexed as

diseaseoxytocinplasticitysensorysynapse

Identifiers

PMID32063835
PMCPMC7000660

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.