ReviewFunctional ecology2020
Why leveraging sex differences in immune trade-offs may illuminate the evolution of senescence.
Review in Functional ecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Interacting effects of sex and age on immune responses in a polygynous bat with male-biased mortality.bioRxiv : the preprint server for biology · 2026Article
- Transcriptome analysis of ageing in a long-lived seabird reveals sex-specific differences across age classes in immune and DNA repair pathways.Frontiers in aging · 2026Article
- Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology.Annals of the New York Academy of Sciences · 2025Review
- Retrospective analysis of pembrolizumab-related adverse reactions and death outcomes based on the FAERS database.BMC cancer · 2025Article
- Sex-dependent effects of infection on guppy reproductive fitness and offspring parasite resistance.The Journal of animal ecology · 2025Article
- Explanations for failures in designed and evolved systems.PNAS nexus · 2025Article
- Parent-Specific Transgenerational Immune Priming Enhances Offspring Defense-Unless Heat Stress Negates It All.Ecology and evolution · 2024Article
- Testing androgen-induced immunosuppression: Environmental androgens as a model system for steroid-immune interaction.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Immune regulation based on sex differences in ischemic stroke pathology.Frontiers in immunology · 2023Review
- Mouse Models forPathogens (Basel, Switzerland) · 2022Review
- Effects of manipulated food availability and seasonality on innate immune function in a passerine.The Journal of animal ecology · 2022Article
- Women with lower systemic inflammation demonstrate steeper cognitive decline with age: Results from a large prospective, longitudinal sample.Brain, behavior, & immunity - health · 2022Article
- The transition between acute and chronic infections in light of energy control: a mathematical model of energy flow in response to infection.Journal of the Royal Society, Interface · 2022Article
- Sex Differences in Biological Systems and the Conundrum of Menopause: Potential Commonalities in Post-Menopausal Disease Mechanisms.International journal of molecular sciences · 2022Review
- Sexual dimorphism in immune function and oxidative physiology across birds: The role of sexual selection.Ecology letters · 2022Article
- A synthesis of senescence predictions for indeterminate growth, and support from multiple tests in wild lake trout.Proceedings. Biological sciences · 2022Article
- Fly immunity comes of age: The utility ofFrontiers in aging · 2022Article
- Respiratory Disease Risk of Zoo-Housed Bonobos Is Associated with Sex and Betweenness Centrality in the Proximity Network.Animals : an open access journal from MDPI · 2021Article
- Immune activation affects whole-organism performance in male but not female green anole lizards (Anolis carolinensis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity.BMC biology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system affects senescence (declines in probabilities of survival or reproduction with age), by shaping late age vulnerability to chronic inflammatory diseases and infections. It is also a dynamic interactive system that must balance competing demands across the life course. Thus, immune system function remains an important frontier in understanding the evolution of senescence.Here, we review our expanding mechanistic understanding of immune function over the life course, in the context of theoretical predictions from life-history evolution. We are especially interested in stage- and sex-dependent costs and benefits of investment in the immune system, given differential life-history priorities of the life stages and sexes.We introduce the costs likely to govern immune allocation across the life course. We then discuss theoretical expectations for differences between the sexes and their likely consequences in terms of how the immune system is both modulated by and may modulate senescence, building on information from life-history theory, experimental immunology and demography.We argue that sex differences in immune function provide a potentially powerful probe of selection pressures on the immune system across the life course. In particular, differences in 'competing' and 'caring' between the sexes have evolved across the tree of life, providing repeated instances of divergent selection pressures on immune function occurring within the same overall bauplan.We conclude by detailing an agenda for future research, including development of theoretical predictions of the differences between the sexes under an array of existing models for sex differences in immunity, and empirical tests of such predictions across the tree of life. A free http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.13458/suppinfo can be found within the Supporting Information of this article.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.