ArticleTuberculosis (Edinburgh, Scotland)2020
Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.
Article in Tuberculosis (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilot.Frontiers in epidemiology · 2026Article
- Lineages of Mycobacterium tuberculosis complex associated with pulmonary drug-resistant tuberculosis in Africa: a systematic review.BMJ public health · 2026Article
- Deep learning on longitudinal CT scans: automated prediction of treatment outcomes in hospitalized tuberculosis patients.iScience · 2023Article
- Afro-TB dataset as a large scale genomic data of Mycobacterium tuberuclosis in Africa.Scientific data · 2023Article
- Fine-grain population structure and transmission patterns ofMicrobial genomics · 2022Article
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundMozambique is a high-burden tuberculosis (TB) country where TB/HIV co-infection and drug resistant TB (DR-TB) incidence is increasing. Whole genome sequencing (WGS) comprehensively describes the molecular epidemiology of TB, allows prediction of DR-TB phenotypes, lineages strains identification and better understanding of transmission chains.
objectiveTo describe genetic diversity of DR-TB Mycobacterium tuberculosis isolated in Beira, Mozambique.
methodsDescriptive cross-sectional study with 35 M. tuberculosis isolates, resistant to at least one first-line drug on molecular drug-susceptibility tests (DST). Variant identification, DR prediction and phylogenetic analysis provided by WGS, drug-susceptibility pattern compared to line-probe assay (LPA): Genotype MTBDR
findingsLineage 4 (L4) was the most prevalent: 25 (71.4%) isolates; 5 (14.3%) L1 and 5 (14.3%) L2. WGS showed 33/35 (94.3%) isolates resistant to at least one drug, two pan-susceptible isolates that were previously diagnosed as DR-TB with genotype MTBDRplus. Concordance between WGS and LPA: 88.6% for isoniazid (INH), 85.7% to rifampicin (RPM), 91.4% for quinolones and 100% to second line injectable drugs. There were three possible TB transmission chains, 10 strains showing recent transmission.
conclusionWGS provided reliable information about the most frequent lineages related to DR-TB in Beira, Mozambique: L4.3 (LAM), L2 (Beijing) and L1 (EAI) and possible recent transmission chain.
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