Evidence map›Paper›PMID 32063089›Full record

Trial reportStress (Amsterdam, Netherlands)2020

Impact of a nutritional supplement during gestation and early childhood on child salivary cortisol, hair cortisol, and telomere length at 4-6 years of age: a follow-up of a randomized controlled trial.

Brietta M Oaks, Seth Adu-Afarwuah, Sika Kumordzie, Mark L Laudenslager, Dana L Smith, Jue Lin, Rebecca R Young, Charles D Arnold, Helena Bentil, Harriet Okronipa and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stress (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Brietta M OaksDepartment of Nutrition and Food Sciences, University of Rhode Island, Kingston, RI, USA.ORCID 0000-0001-6056-0585
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Legon, Ghana.
Sika KumordzieDepartment of Nutrition, University of California, Davis, CA, USA.
Mark L LaudenslagerDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dana L SmithDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Rebecca R YoungDepartment of Nutrition, University of California, Davis, CA, USA.
Charles D ArnoldDepartment of Nutrition, University of California, Davis, CA, USA.ORCID 0000-0001-6510-3172
Helena BentilDepartment of Nutrition and Food Sciences, University of Rhode Island, Kingston, RI, USA.
Harriet OkronipaDepartment of Nutrition, University of California, Davis, CA, USA.ORCID 0000-0002-5373-6754
Maku OcanseyDepartment of Nutrition, University of California, Davis, CA, USA.ORCID 0000-0001-9275-7526
Kathryn G DeweyDepartment of Nutrition, University of California, Davis, CA, USA.ORCID 0000-0002-4185-3451
University of California, Davis · USUniversity of California, San Francisco · USUniversity of Rhode Island · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of the stress response can occur early in life and may be affected by nutrition. Our objective was to evaluate the long-term effect of nutritional supplementation during gestation and early childhood on child cortisol and buccal telomere length (a marker of cellular aging) at 4-6 years of age. We conducted a follow-up study of children born to women who participated in a nutritional supplementation trial in Ghana. In one group, a lipid-based nutrient supplement (LNS) was provided to women during gestation and the first 6 months postpartum and to their infants from age 6 to 18 months. The control groups received either iron and folic acid (IFA) during gestation or multiple micronutrients during gestation and the first 6 months postpartum, with no infant supplementation. At age 4-6 years, we measured hair cortisol, buccal telomere length, and salivary cortisol before and after a stressor. Salivary cortisol was available for 364 children across all three trial arms and hair cortisol and telomere length were available for a subset of children (

Indexed as

HydrocortisoneTelomereAdolescentChildChild, PreschoolDietary SupplementsFemaleFollow-Up StudiesGhanaHumansInfantMicronutrientsPregnancyStress, PsychologicalHydrocortisoneMicronutrientschildCortisolnutritionpregnancytelomere length

Identifiers

PMID32063089
PMCPMC7497284
OpenAlexW3008546522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.