Evidence map›Paper›PMID 32063061›Full record

ReviewHypertension (Dallas, Tex. : 1979)2020

Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation.

Curt D Sigmund, Robert M Carey, Lawrence J Appel, Donna K Arnett, Hayden B Bosworth, William C Cushman, Zorina S Galis, Melissa Green Parker, John E Hall, David G Harrison and 7 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. From Co-Design to Quality Improvement: Using the Double Diamond Framework to Develop Primary Care Redesign Priorities for Hypertension Care.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 1 country.

Curt D SigmundFrom the Department of Physiology, Medical College of Wisconsin, Milwaukee (C.D.S.).
Robert M CareyDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia, Charlottesville (R.M.C.).
Lawrence J AppelDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (L.J.A.).
Donna K ArnettUniversity of Kentucky, Lexington (D.K.A.).
Hayden B BosworthDuke University, Durham Veterans Affairs Medical Center, Durham, NC (H.B.B.).
William C CushmanMedical Service, Veterans Affairs Medical Center, Memphis, TN (W.C.C.).
Zorina S GalisVascular Biology & Hypertension Branch, DCVS, NHLBI (Z.S.G.).
Melissa Green ParkerHealth Inequities and Global Health Branch, CTRIS, NHLBI (M.G.P.).
John E HallDepartment of Physiology & Biophysics, University of Mississippi Medical Center, Jackson (J.E.H.).
David G HarrisonVanderbilt University, Nashville, TN (D.G.H.).
Alicia A McDonoughDepartment of Physiology and Biophysics, University of Southern California, Los Angeles (A.A.M.).
Holly L NicastroClinical Applications and Prevention Branch, DCVS, NHLBI (H.L.N.).
Suzanne OparilUniversity of Alabama at Birmingham (S.O.).
John W OsbornUniversity of Minnesota, Minneapolis (J.W.O.).
Mohan K RaizadaUniversity of Florida, Gainesville (M.K.R.).
Jacqueline D WrightEpidemiology Branch, DCVS, NHLBI (J.D.W.).
Young S OhVascular Biology and Hypertension Branch, DCVS, NHLBI (Y.S.O.).
Duke University · USJackson Memorial Hospital · USJohns Hopkins Medicine · USMedical College of Wisconsin · USParker Hannifin (United States) · USUniversity of Alabama at Birmingham · USUniversity of Florida · USUniversity of Kentucky · USUniversity of Minnesota · USUniversity of Southern California · USUniversity of Virginia · USVanderbilt University · USVeterans Health Administration · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI KWITEK, ANNE E. · 2007 to 2022
$30.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
The Role of Inflammation in Cardiovascular DiseaseP01HL129941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2016 to 2020
$12.4M
Sodium transporter regulation during hypertensionR01DK083785 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AURELIE EDWARDS, Alicia A. McDonough · 2011 to 2026
$5.8M
PPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5M
Mechanisms of Immune Activation in HypertensionR35HL140016 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 2018 to 2024
$5.3M
Assess and Adapt to the Impact of COVID-19 on CVD Self Management and Prevention Care in Adults Living with HIV (AAIM-High)U01HL142099 · NHLBI · UNIVERSITY OF WASHINGTON · PI BOSWORTH, HAYDEN B, LONGENECKER, CHRIS TODD · 2018 to 2021
$4.8M
Dissemination and Implementation Science in Cardiovascular Outcomes (DISCO)K12HL138030 · NHLBI · DUKE UNIVERSITY · PI BOSWORTH, HAYDEN B · 2017 to 2021
$3.9M
HSR&D Senior Research Career Scientist AwardIK6HX003161 · VA · DURHAM VA MEDICAL CENTER · PI Hayden B Bosworth · 2020 to 2026
–
HSRD VA IK6 HX003161NHLBI NIH HHS K12 HL138030NHLBI NIH HHS P01 HL084207NHLBI NIH HHS P01 HL129941NHLBI NIH HHS R35 HL140016NHLBI NIH HHS R35 HL144807NHLBI NIH HHS U01 HL142099NIDDK NIH HHS R01 DK083785
6 · The paper itself

Abstract

The National Heart, Lung, and Blood Institute convened a multidisciplinary working group of hypertension researchers on December 6 to 7, 2018, in Bethesda, MD, to share current scientific knowledge in hypertension and to identify barriers to translation of basic into clinical science/trials and implementation of clinical science into clinical care of patients with hypertension. The goals of the working group were (1) to provide an overview of recent discoveries that may be ready for testing in preclinical and clinical studies; (2) to identify gaps in knowledge that impede translation; (3) to highlight the most promising scientific areas in which to pursue translation; (4) to identify key challenges and barriers for moving basic science discoveries into translation, clinical studies, and trials; and (5) to identify roadblocks for effective dissemination and implementation of basic and clinical science in real-world settings. The working group addressed issues that were responsive to many of the objectives of the National Heart, Lung, and Blood Institute Strategic Vision. The working group identified major barriers and opportunities for translating research to improved control of hypertension. This review summarizes the discussion and recommendations of the working group.

Indexed as

Clinical Trials as TopicHypertensionTranslational Research, BiomedicalAnimalsHumansclinical trialgoalsimmunologyknowledgescience

Identifiers

PMID32063061
PMCPMC7067675
OpenAlexW3012406812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.