SynthesisCirculation. Cardiovascular quality and outcomes2020
Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Circulation. Cardiovascular quality and outcomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Effects of sodium tanshinone IIA sulfonate injection on inflammatory factors and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A systematic review and meta-analysis of randomized clinical trials.Frontiers in pharmacology · 2023Pooled it
- Invasive therapy versus conservative therapy for patients with stable coronary artery disease: An updated meta-analysis.Clinical cardiology · 2021Pooled it
- Death and Myocardial Infarction Following Initial Revascularization Versus Optimal Medical Therapy in Chronic Coronary Syndromes With Myocardial Ischemia: A Systematic Review and Meta-Analysis of Contemporary Randomized Controlled Trials.Journal of the American Heart Association · 2021Pooled it
- Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA.Circulation · 2025Trial
- A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina.The New England journal of medicine · 2023Trial
- Invasive and medical management approaches to non-acute myocardial ischaemic syndromes.Nature reviews. Cardiology · 2026Review
- Assessing the mortality burden after acute myocardial infarction in SLE: insights from the MINAP Registry.Rheumatology (Oxford, England) · 2026Article
- Cardiac Biomarkers to Refine Pretest Probability for Coronary Obstruction and Predict Survival After Revascularization in Chronic Coronary Syndrome.Journal of the American Heart Association · 2026Observational
- IgG N-Glycosylation During Atorvastatin Therapy After Acute Coronary Syndrome is Associated with LDL Cholesterol Reduction.Journal of clinical medicine · 2026Article
- Community-Level Procedure Volume and Patient Health Profiles Following PCI-Capable Facility Openings.JAMA network open · 2026Article
- Coronary Artery Bypass Grafting Following ST Elevation Myocardial Infarction Outcomes Are Associated with Time to Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Predicting Occlusion Myocardial Infarctions in the Emergency Department Using Artificial Intelligence.Journal of the American College of Emergency Physicians open · 2026Article
- Observational
- Percutaneous coronary intervention plus guideline-directed medical therapy (GDMT) versus GDMT alone in adults with stable coronary artery disease.The Cochrane database of systematic reviews · 2026Article
- The association between coronary microvascular dysfunction and HbA1c in patients with unstable angina pectoris.Frontiers in cardiovascular medicine · 2026Article
- Prediction of post-PCI angina risk using machine learning-based magnetocardiography model.Frontiers in cardiovascular medicine · 2026Article
- Necessity of Percutaneous Coronary Intervention Evaluated by Low-Pressure Balloon Occlusion and Improvement of Postoperative Clinical Symptoms in Patients with Intermediate Lesions.International journal of general medicine · 2026Article
- Symptom Burden in Patients with Acute Coronary Syndrome After Percutaneous Coronary Intervention: A Network and Latent Profile Analysis.Patient preference and adherence · 2026Article
- Association between Percutaneous Coronary Intervention and Long-Term Clinical Outcomes in Patients with Chronic Kidney Disease and Acute Myocardial Infarction.Cardiorenal medicine · 2026Article
- Changes of Serum CTRP12 in Patients With Coronary Artery Disease After the Treatment of Percutaneous Coronary Intervention and Its Relationship With In-Stent Restenosis.Clinical cardiology · 2026Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn patients presenting with ST-segment-elevation myocardial infarction, percutaneous coronary intervention (PCI) reduces mortality when compared with fibrinolysis. In other forms of coronary artery disease (CAD), however, it has been controversial whether PCI reduces mortality. In this meta-analysis, we examine the benefits of PCI in (1) patients post-myocardial infarction (MI) who did not receive immediate revascularization; (2) patients who have undergone primary PCI for ST-segment-elevation myocardial infarction but have residual coronary lesions; (3) patients who have suffered a non-ST-segment-elevation acute coronary syndrome; and (4) patients with truly stable CAD with no recent infarct. This analysis includes data from the recently presented International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) and Complete versus Culprit-Only Revascularization Strategies to Treat Multivessel Disease after Early PCI for STEMI (COMPLETE) trials. METHODS AND
resultsWe systematically identified all randomized trials of PCI on a background of medical therapy for the treatment of CAD. The ISCHEMIA trial, presented in November 2019, was eligible for inclusion. Data were combined using a random-effects meta-analysis. The primary end point was all-cause mortality. Forty-six trials, including 37 757 patients, were eligible. In the 3 unstable scenarios, PCI had the following effects on mortality: unrevascularized post-MI relative risk (RR) 0.68 (95% CI, 0.45-1.03);
conclusionsPCI prevents death, cardiac death, and MI in patients with unstable CAD. For patients with stable CAD, PCI shows no evidence of an effect on any of these outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.