Evidence map›Paper›PMID 32062798›Full record

ArticleMikrochimica acta2020

Fluorometric immunoassay for the simultaneous determination of the tumor markers carcinoembryonic antigen and cytokeratin 19 fragment using two kinds of CdSe/ZnS quantum dot nanobeads and magnetic beads.

Lihua Ding, Xiao Chen, Leiliang He, Fei Yu, Songcheng Yu, Jia Wang, Yongmei Tian, Yilin Wang, Yongjun Wu, Li-E Liu and 1 more

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lihua DingCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Xiao ChenCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Leiliang HeCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Fei YuCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Songcheng YuCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Jia WangCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Yongmei TianCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Yilin WangCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Yongjun WuCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China. wuyongjun135@126.com.ORCID http://orcid.org/0000-0002-0509-7521
Li-E LiuCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China. zzdxlle66@126.com.
Lingbo QuCollege of Public Health, Zhengzhou University, Zhengzhou, 450001, China. zhengdacpu@163.com.
Zhengzhou University · CN

Funding

National Natural Science Foundation of China 21605131National Natural Science Foundation of China 81573203National Natural Science Foundation of China 81973099Science and Technology Department of Henan Province 172102210006
6 · The paper itself

Abstract

A method is described for the simultaneous determination of the carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21-1). Two kinds of CdSe/ZnS quantum dot nanobeads (QBs), with emission maxima at 530 nm (green) and 585 nm (yellow), were used as labels, and magnetic beads (MBs) for separation. The MBs were used as substrates to couple CEA and CYFRA21-1 antibody for isolating the proteins. Then, the differently colored QBs were linked to the antibodies against CEA and CYFRA21-1, respectively. Following the formation of the immunocomplex, the intensities of the green and yellow emissions were measured at the same excitation wavelength of 340 nm. The detection limits are 0.1 ng⋅mL

Indexed as

Biomarkers, TumorCadmium CompoundsCarcinoembryonic AntigenFluorometryHumansImmunoassayKeratin-19Magnetic PhenomenaQuantum DotsSulfidesZinc CompoundsBiomarkers, TumorCadmium CompoundsCarcinoembryonic AntigenKeratin-19SulfidesZinc Compoundszinc sulfideAntibodyFluorescenceHuman serumLung cancerMultiplexed detection

Identifiers

PMID32062798
OpenAlexW3006546490

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.