SynthesisEnvironmental science and pollution research international2020
Toxicity testing of pesticides in zebrafish-a systematic review on chemicals and associated toxicological endpoints.
Synthesis in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Pesticide bioavailability, bioaccumulation, and bioconcentration in zebrafish: a critical review with emphasis on methodological inadequacies.Archives of toxicology · 2026Review
- Comparative toxicity of plant protection products, their active substances and mixtures in zebrafish embryos and HepaRG cells.Archives of toxicology · 2026Article
- Small fish making a big difference: beloved star of environmental toxicology research in the current era.Journal of Zhejiang University. Science. B · 2025Review
- Metabolic Disruptions in Zebrafish Induced by α-Cypermethrin: A Targeted Metabolomics Study.Toxics · 2025Article
- Combined Neurotoxic Effects of Commercial Formulations of Pyrethroid (Deltamethrin) and Neonicotinoid (Imidacloprid) Pesticides on Adult Zebrafish (Life (Basel, Switzerland) · 2025Article
- Laboratory and physiological aspects of substitute metazoan models for in vivo pharmacotoxicological analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees.Heliyon · 2025Article
- The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Review
- Embryotoxicity Induced by Triclopyr in Zebrafish (Toxics · 2024Article
- Towards improved screening of toxins for Parkinson's risk.NPJ Parkinson's disease · 2023Review
- Comparative analysis between zebrafish and an automated live-cell assay to classify developmental neurotoxicant chemicals.Toxicology and applied pharmacology · 2023Article
- Progress and promise of alternative animal and non-animal methods in biomedical research.Archives of toxicology · 2023Review
- Recent Advances in Rapid Detection Techniques for Pesticide Residue: A Review.Journal of agricultural and food chemistry · 2022Review
- Combined toxicities of cadmium and five agrochemicals to the larval zebrafish (Danio rerio).Scientific reports · 2022Article
- Antimicrobial Effectiveness of Innovative Photocatalysts: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss.Frontiers in public health · 2022Review
- Influence of Geomagnetic Disturbances at Different Times of Day on Locomotor Activity in Zebrafish (Danio Rerio).Clocks & sleep · 2021Article
- Wild Zebrafish Sentinels: Biological Monitoring of Site Differences Using Behavior and Morphology.Toxics · 2021Article
- Synthetic organic chemicals (flame retardants and pesticides) with neurotoxic potential induced behavioral impairment on zebrafish (Danio rerio): a non-invasive approach for neurotoxicology.Environmental science and pollution research international · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The use of zebrafish (Danio rerio) has arisen as a promising biological platform for toxicity testing of pesticides such as herbicides, insecticides, and fungicides. Therefore, it is relevant to assess the use of zebrafish in models of exposure to investigate the diversity of pesticide-associated toxicity endpoints which have been reported. Thus, this review aimed to assess the recent literature on the use of zebrafish in pesticide toxicity studies to capture data on the types of pesticide used, classes of pesticides, and zebrafish life stages associated with toxicity endpoints and phenotypic observations. A total of 352 articles published between September 2012 and May 2019 were curated. The results show an increased trend in the use of zebrafish for testing the toxicity of pesticides, with a great diversity of pesticides (203) and chemical classes (58) with different applications (41) being used. Furthermore, experimental outcomes could be clustered in 13 toxicity endpoints, mainly developmental toxicity, oxidative stress, and neurotoxicity. Organophosphorus, pyrethroid, azole, and triazine were the most studied classes of pesticides and associated with various toxicity endpoints. Studies frequently opted for early life stages (embryos and larvae). Although there is an evident lack of standardization of nomenclatures and phenotypic alterations, the information gathered here highlights associations between (classes of) pesticides and endpoints, which can be used to relate mechanisms of action specific to certain classes of chemicals.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.