ReviewNeuroradiology2020
The splenium of the corpus callosum: embryology, anatomy, function and imaging with pathophysiological hypothesis.
Review in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Cytotoxic lesions of the corpus callosum: a systematic review.European radiology · 2024Pooled it
- White matter alterations in Attention-Deficit/Hyperactivity Disorder (ADHD): a systematic review of 129 diffusion imaging studies with meta-analysis.Molecular psychiatry · 2023Pooled it
- Alexithymia mediates white-matter microstructure and substance use escalation in trauma-exposed individuals.Journal of affective disorders · 2026Article
- Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-chronic Lithium Toxicity.Internal medicine (Tokyo, Japan) · 2026Article
- Ischemic Stroke of the Corpus Callosum Mimicking Cerebellar-Type Ataxia: A Case Report and Diagnostic Pitfall.Cureus · 2026Article
- Brain structural MRI changes before and after 6 months of preventive treatment with erenumab and onabotulinumtoxinA in migraine.The journal of headache and pain · 2026Article
- Deciphering the dynamics of the splenium: A comprehensive analysis of flair hyperintensity variations.Experimental and therapeutic medicine · 2026Article
- Microstructural Alterations of the Corpus Callosum in Patients with First-Episode Schizophrenia Revealed by NODDI: Dissociation Between Neurite Density and Orientation Dispersion in the Splenium.Bioengineering (Basel, Switzerland) · 2026Article
- Mapping corpus callosum architecture: developmental, genetic, and cognitive correlates in youth.bioRxiv : the preprint server for biology · 2026Article
- Revisiting retrosplenial amnesia: Injury of the crus of the fornix following splenial hemorrhage - A 3D magnetic resonance imaging case report.Journal of clinical imaging science · 2026Article
- Article
- Long-term cognitive outcomes of Chiari II malformation and corpus callosum abnormalities in myelomeningocele.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Article
- Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium.Translational psychiatry · 2025Article
- Splenial lesions of the corpus callosum: a comprehensive study on etiology, clinical presentation, radiological features, and prognostic insights.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum in Chinese Patients: A Retrospective Study.Brain and behavior · 2025Article
- Association of microstructural lesions of the corpus callosum with cognitive impairment in patients with high grade glioma.Acta neurochirurgica · 2025Article
- Reversible Splenial Lesion Syndrome Induced by Paracetamol and Lithium: A Report of Two Cases and Literature Review.Cureus · 2025Article
- Distinguishing Early from Late Mild Cognitive Impairment Using Magnetic Resonance Free-Water Diffusion Tensor Imaging.NeuroSci · 2025Article
- Reversible splenial lesion syndrome associated with Graves' disease and hepatic dysfunction: a case report.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe splenium of the corpus callosum is the most posterior part of the corpus callosum. Its embryological development, anatomy, vascularization, function, imaging of pathology, possible pathophysiological mechanisms by which pathology may develop and the clinical consequences are discussed.
methodsA literature-based description is provided on development, anatomy and function. MR and CT images are used to demonstrate pathology. The majority of pathology, known to affect the splenium, and the clinical effects are described in three subsections: (A) limited to the splenium, with elaboration on pathophysiology of reversible splenial lesions, (B) pathology in the cerebral white matter extending into or deriving from the splenium, with special emphasis on tumors, and (C) splenial involvement in generalized conditions affecting the entire brain, with a hypothesis for pathophysiological mechanisms for the different diseases.
resultsThe development of the splenium is preceded by the formation of the hippocampal commissure. It is bordered by the falx and the tentorium and is perfused by the anterior and posterior circulation. It contains different caliber axonal fibers and the most compact area of callosal glial cells. These findings may explain the affinity of specific forms of pathology for this region. The fibers interconnect the temporal and occipital regions of both hemispheres reciprocally and are important in language, visuospatial information transfer and behavior. Acquired pathology may lead to changes in consciousness.
conclusionThe development, location, fiber composition and vascularization of the splenium make it vulnerable to specific pathological processes. It appears to play an important role in consciousness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.