ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020
Quality of life may be a more valuable prognostic factor than depression in older hemodialysis patients.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Early mobilization program with nonweight-bearing brace improves functional capacity after diabetic foot ulcer surgery: a randomized controlled trial.Langenbeck's archives of surgery · 2025Trial
- Response to Comment: Testosterone deficiency in men with end-stage renal disease and kidney transplantation: a narrative review.International journal of impotence research · 2026Article
- Metabolic-Nutritional Associations with Depression in Elderly Chronic Kidney Disease Patients: Hemodialysis Versus Non-Dialysis Populations.Metabolites · 2025Article
- Overlap of Depressive Symptoms with Health-Related Quality-of-Life Measures.PharmacoEconomics · 2021Article
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Abstract
purposeDepression and impairment of quality of life (QoL) reduce the survival of individual on hemodialysis (HD). However, few studies evaluated the impact of these conditions on the survival of older patients undergoing HD.
methodsA retrospective cohort study was performed including patients aged ≥ 60 years on HD in Recife, Brazil, assessed in 2013 and monitored until 2017. Depression was evaluated with the Mini-International Neuropsychiatric Interview and QoL with the Control, Autonomy, Self-realization, and Pleasure Questionnaire (CASP-16). Survival differences according to the depression and QoL status were measured by Kaplan-Meier analysis and Cox regression. Death Certificates were analyzed to assess the cause of death.
resultsA total of 171 patients were included (mean age 68.7 ± 6.9 years). The mean follow-up time was 3 years (maximum 4.5 years) and there were 98 deaths (57.3% of the sample). In a multivariate model that included depression and QoL, only QoL impairment was associated with a higher risk of death (HR 1.62, p = 0.035). Among CASP domains, only "Control" was associated with survival (HR 0.90, p = 0.014). Depression was unrelated to the cause of death, but there was a trend for death by endocrine diseases if QoL was impaired (p = 0.057).
conclusionQoL impairment is a key predictor of prognosis in older patients on HD and may be more important than depression. It is important that teams dealing with this population include in protocols an assessment of QoL, in order to offer a range of care according to the needs of these patients.
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