ArticleInvestigational new drugs2020
Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity.
Article in Investigational new drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Toxicity Effect of Hypnea flagelliformis Algae on Cancerous Mitochondria Obtained from Rat Model of Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- New naphthalene-linked pyrazoline-thiazole hybrids as prominent antilung and antibreast cancer inhibitors.Turkish journal of chemistry · 2024Article
- Gypsogenin Battling for a Front Position in the Pentacyclic TriterpenesMolecules (Basel, Switzerland) · 2023Review
- Evaluation of anti-glioma effects of benzothiazoles as efficient apoptosis inducers and DNA cleaving agents.Molecular and cellular biochemistry · 2023Article
- Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects.Molecules (Basel, Switzerland) · 2022Article
- Evaluation of In Vitro Cytotoxic Potential of Avarol towards Human Cancer Cell Lines and In Vivo Antitumor Activity in Solid Tumor Models.Molecules (Basel, Switzerland) · 2022Article
- Marine SpongePharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Antiproliferation Effects of Marine-Sponge-Derived Methanol Extract ofAntioxidants (Basel, Switzerland) · 2022Article
- Ilimaquinone (Marine Sponge Metabolite) Induces Apoptosis in HCT-116 Human Colorectal Carcinoma Cells via Mitochondrial-Mediated Apoptosis Pathway.Marine drugs · 2022Article
- In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment.Molecules (Basel, Switzerland) · 2022Article
- A New Series of Indeno[1,2-Molecules (Basel, Switzerland) · 2022Article
- Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources.Pharmaceuticals (Basel, Switzerland) · 2021Review
- EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.International journal of molecular sciences · 2021Article
- Secondary Metabolites from Marine Sources with Potential Use as Leads for Anticancer Applications.Molecules (Basel, Switzerland) · 2021Review
- Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Oxidative Stress Mediated Cytotoxicity, Cell Cycle Arrest, and Apoptosis Induced byOxidative medicine and cellular longevity · 2021Article
- In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors.Molecules (Basel, Switzerland) · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine natural products have drawn a great deal of attention as a vital source of new drugs for the last five decades. However, marine organisms in the seas surrounding Turkey (the Black Sea, the Aegean Sea and the Mediterranean Sea) haven't been yet extensively explored. In the present study, three marine organisms (Dysidea avara, Microcosmus sabatieri and Echinaster sepositus) were sampled from the Dardanelles (Turkish Straits System, Western Turkey) by scientific divers, transferred to the laboratory and then were extracted with 70% ethanol. The extracts were tested for their cytotoxic effect against K562, KMS-12PE, A549, and A375 cancer cell lines. The sponge extract elicited the most promising cytotoxic activity, thus it was further evaluated against H929, MCF-7, HeLa, and HCT116 cancer cells. Most of the designated cells showed a considerable sensitivity for the sponge extract particularly H929, K562, KMS-12PE and HeLa cells with IC
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