Evidence map›Paper›PMID 32062688›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Infant milk feeding and bone health in later life: findings from the Hertfordshire cohort study.

S A Carter, C M Parsons, S M Robinson, N C Harvey, K A Ward, C Cooper, E M Dennison

Abstract read
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Observational
  3. Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

S A CarterMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID http://orcid.org/0000-0001-6575-3482
C M ParsonsMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
S M RobinsonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
N C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
K A WardMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
C CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK. cc@mrc.soton.ac.uk.
E M DennisonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
Southampton General Hospital · GBMRC Human Nutrition Research · GB

Funding

Medical Research Council MC_U105960371Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Versus Arthritis 19583
6 · The paper itself

Abstract

Using data from the Hertfordshire cohort study, this study examined the effect of breastfeeding and bottle feeding on adult lumbar spine and femoral neck bone mineral content (BMC) and bone mineral density (BMD). The type of infant milk feeding was significantly associated with lumbar spine BMD in males.

introductionUsing data from the Hertfordshire cohort study (HCS), this study aims to examine the effect of infant milk feeding on bone health in later life by comparing the effect of breastfeeding and bottle feeding on lumbar spine and femoral neck BMC and BMD.

methodsInformation about infant milk feeding, birth weight (kg) and weight at 1 (kg) was collected by health visitors between 1931 and 1939 in Hertfordshire. BMC and BMD measurements were taken by DXA scan between 1998 and 2004. Linear regression models adjusted for conditional weight at 1, age at DXA scan, sex, adult BMI, smoking behaviour, alcohol consumption, physical activity, dietary calcium, and prudent diet score.

resultsInfant milk feeding was significantly associated with lumbar spine BMD (b = - 0.028; 95% CI, - 0.055; - 0.000; p value, 0.047) in males. On average, males who consumed breastmilk alternatives in infancy had lower lumbar spine BMD measurements than those who were fed only breastmilk. These associations remained significant in fully adjusted models. There were no significant associations between infant milk feeding and bone health for females.

conclusionsSignificant associations between infant milk feeding and lumbar spine BMD in males indicate that breastmilk may be protective for the bone health of male babies. The evidence presented here underscores the potential lifelong benefits of breastfeeding and may highlight the differences between osteoporotic risk factors for males and females.

Indexed as

Bone DensityFemur NeckMilk, HumanAbsorptiometry, PhotonAdultCohort StudiesFemaleHumansInfantLumbar VertebraeMaleBone and bonesBottle feedingBreastfeedingOsteoporosis

Identifiers

PMID32062688
OpenAlexW3005393191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.