ArticleEnvironment international2020
Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident.
Article in Environment international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- A community-engaged randomized controlled trial assessing the effectiveness of a weight loss aid in reducing the body burden of persistent organic pollutants.Environmental advances · 2026Article
- Associations between persistent organic pollutants and thyroid-related hormones and homeostasis parameters in middle-aged to older men and postmenopausal women: The HCHS/SOL.Environmental research · 2025Article
- Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish.Environmental toxicology and chemistry · 2025Article
- Mortality of individuals in a long-term cohort exposed to polybrominated biphenyls (PBBs).Environmental health : a global access science source · 2025Article
- A State of the Science Review of Human Health Effects of the Michigan Polybrominated Biphenyl Contamination after Five Decades.Environmental health perspectives · 2025Review
- Extrapolation of PBBs Environmental Transformation Mechanisms and Toxicity Risks of Byproducts.International journal of molecular sciences · 2025Article
- Endocrine disruptors, obesity, and metabolic syndrome.Turkish journal of medical sciences · 2025Review
- Associations between brominated flame retardants, including polybrominated diphenyl ethers, and immune responses among women in the California Teachers Study.Frontiers in epidemiology · 2025Article
- Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish.bioRxiv : the preprint server for biology · 2024Article
- Changes in Adipose Tissue and Circulating Concentrations of Persistent Organic Pollutants in Midlife Women.Environment & health (Washington, D.C.) · 2024Article
- Exploring autism spectrum disorder (ASD) and attention deficit disorder (ADD/ADHD) in children exposed to polybrominated biphenyl.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- In-utero exposure to polybrominated biphenyl (PBB) and menstrual cycle function in adulthood.International journal of hygiene and environmental health · 2024Article
- Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry.Environmental research · 2023Article
- The Covalent Linking of Organophosphorus Heterocycles to Date Palm Wood-Derived Lignin: Hunting for New Materials with Flame-Retardant Potential.Molecules (Basel, Switzerland) · 2023Article
- Assessing Metabolic Differences Associated with Exposure to Polybrominated Biphenyl and Polychlorinated Biphenyls in the Michigan PBB Registry.Environmental health perspectives · 2023Article
- Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures.The Science of the total environment · 2023Article
- Inheritance of paternal lifestyles and exposures through sperm DNA methylation.Nature reviews. Urology · 2023Review
- Elimination of PBB-153; findings from a cohort of Michigan adults.Environmental research · 2023Article
- Associations of brominated flame retardants exposure with chronic obstructive pulmonary disease: A US population-based cross-sectional analysis.Frontiers in public health · 2023Article
- Assessing disparities in Americans' exposure to PCBs and PBDEs based on NHANES pooled biomonitoring data.Journal of the American Statistical Association · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Widespread polybrominated biphenyls (PBBs) contamination occurred in Michigan from 1973 to 1974, when PBBs were accidentally substituted for a nutritional supplement in livestock feed. People who lived in the state were exposed to PBBs via several routes including ingestion, inhalation and skin absorption. PBBs sequestered in lipid-rich matrices such as adipose tissue, are slowly eliminated after entering the human body, and can also be transferred from a mother to her offspring through the placenta and breastfeeding. Due to the long biological half-lives of PBBs, as well as concerns from the exposed community, biomonitoring measurements were conducted from 2012 to 2015. Because of their similar structures, serum PBBs, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) were all measured 40 years after the PBB contamination incident (N = 862). The serum PBB-153 levels among the original highly-exposed groups (i.e., chemical workers, the family of chemical workers, and individuals who lived on or received food from the contaminated farms) remains significantly higher than other Michigan residents. Several predictors such as sampling age, sex, and smoking status were significantly associated with the serum levels of some persistent organic pollutants (POPs). Higher average values and also wider ranges of serum POP levels were found in this study compared to the National Health and Nutrition Examination Survey (NHANES), with the most substantial difference in serum PBB-153. This was true for all groups of Michigan residents including those who were not part of the above-described highly-exposed groups. Moreover, the people born after the contamination incident began also have higher serum PBB-153 levels when compared with more recent NHANES data (2010-2014), which suggests potential intergenerational exposure and/or continued environmental exposure following the contamination period.
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