Evidence map›Paper›PMID 32062351›Full record

ArticleEBioMedicine2020

Gut microbiota composition during infancy and subsequent behavioural outcomes.

Amy Loughman, Anne-Louise Ponsonby, Martin O'Hely, Christos Symeonides, Fiona Collier, Mimi L K Tang, John Carlin, Sarath Ranganathan, Katrina Allen, Angela Pezic and 6 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  4. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Amy LoughmanDeakin University, Geelong, Victoria 3220, Australia.
Anne-Louise PonsonbyThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia.
Martin O'HelyDeakin University, Geelong, Victoria 3220, Australia; The Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia.
Christos SymeonidesThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The University of Melbourne, Parkville, Victoria 3052, Australia; The Royal Children's Hospital, Parkville, Victoria 3052, Australia.
Fiona CollierDeakin University, Geelong, Victoria 3220, Australia; The Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; Barwon Health, Geelong, Victoria 3220, Australia.
Mimi L K TangThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The University of Melbourne, Parkville, Victoria 3052, Australia; The Royal Children's Hospital, Parkville, Victoria 3052, Australia.
John CarlinThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The University of Melbourne, Parkville, Victoria 3052, Australia.
Sarath RanganathanThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The University of Melbourne, Parkville, Victoria 3052, Australia; The Royal Children's Hospital, Parkville, Victoria 3052, Australia.
Katrina AllenThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The University of Melbourne, Parkville, Victoria 3052, Australia; The Royal Children's Hospital, Parkville, Victoria 3052, Australia.
Angela PezicThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia.
Richard SafferyThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; The University of Melbourne, Parkville, Victoria 3052, Australia.
Felice JackaDeakin University, Geelong, Victoria 3220, Australia; The Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia.
Leonard C HarrisonThe University of Melbourne, Parkville, Victoria 3052, Australia; The Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia.
Peter D SlyThe Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; University of Queensland, South Brisbane, Queensland 4101, Australia.
Peter VuillerminDeakin University, Geelong, Victoria 3220, Australia; The Murdoch Children's Research Institute, Parkville, Victoria, 3052, Australia; Barwon Health, Geelong, Victoria 3220, Australia. Electronic address: peter.vuillermin@deakin.edu.au.
BIS Investigator Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite intense interest in the relationship between gut microbiota and brain development, longitudinal data from human studies are lacking. This study aimed to investigate the relationship between the composition of gut microbiota during infancy and subsequent behavioural outcomes.

methodsA subcohort of 201 children with behavioural outcome measures was identified within a longitudinal, Australian birth-cohort study. The faecal microbiota were analysed at 1, 6, and 12 months of age. Behavioural outcomes were measured at 2 years of age.

findingsIn an unselected birth cohort, we found a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years, in particular Internalizing Problem scores. This association appeared independent of multiple potentially confounding variables, including maternal mental health. Recent exposure to antibiotics was the best predictor of decreased Prevotella.

interpretationOur findings demonstrate a strong association between the composition of the gut microbiota in infancy and subsequent behavioural outcomes; and support the importance of responsible use of antibiotics during early life.

fundingThis study was funded by the National Health and Medical Research Council of Australia (1082307, 1147980, 1129813), The Murdoch Children's Research Institute, Barwon Health, Deakin University, Perpetual Trustees, and The Shepherd Foundation. The funders had no involvement in the data collection, analysis or interpretation, trial design, recruitment or any other aspect pertinent to the study.

Indexed as

Child BehaviorGastrointestinal MicrobiomeInfant BehaviorNeurogenesisAdultAge FactorsAnti-Bacterial AgentsAustraliaBiodiversityBrainChildChild, PreschoolCohort StudiesFecesFemaleHumansAnti-Bacterial AgentsRNA, Ribosomal, 16SBehaviourGut-brain axisInfantMicrobiota

Identifiers

PMID32062351
PMCPMC7016366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.