Evidence map›Paper›PMID 32061926›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021

Context-Specific Dyadic Attention Vulnerabilities During the First Year in Infants Later Developing Autism Spectrum Disorder.

Suzanne Macari, Anna Milgramm, Jessa Reed, Frederick Shic, Kelly K Powell, Deanna Macris, Katarzyna Chawarska

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Infant responses to direct gaze and associations to autism: A live eye-tracking study.Autism : the international journal of research and practice · 2024
    Article
  10. Social interaction links active musical rhythm engagement and expressive communication in autistic toddlers.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Reduced social attention in autism is magnified by perceptual load in naturalistic environments.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  18. Article
  19. Neonatal neurobehavior in infants with autism spectrum disorder.Developmental medicine and child neurology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Suzanne MacariYale Child Study Center, Yale School of Medicine, New Haven, Connecticut. Electronic address: suzanne.macari@yale.edu.
Anna MilgrammYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Jessa ReedYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Frederick ShicYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Kelly K PowellYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Deanna MacrisYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Katarzyna ChawarskaYale Child Study Center, Yale School of Medicine, New Haven, Connecticut.
Yale University · USYale Cancer Center · US

Funding

TOURETTE'S SYNDROME &RELATED DISORDERS: STUDY OF HIGH DENSITY FAMILIESP01HD003008 · NICHD · YALE UNIVERSITY · PI VOLKMAR, FRED ROBERT · 1985 to 2010
$12.1M
RARE VARIANT GENETICS, CONTACTIN-RELATED PROTEINS AND AUTISMP50MH081756 · NIMH · YALE UNIVERSITY · PI GRIGORENKO, ELENA L · 2008 to 2012
$12.1M
Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$11.5M
Attentional, temperamental, and physiological process underlying anxiety in preschoolers with ASDR01MH111652 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$3.9M
Components of Emotional Processing in Toddlers with ASDR01MH100182 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2013 to 2017
$3.4M
Development of Face Processing in Infants with Autism Spectrum DisordersR01MH087554 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2010 to 2014
$2.0M
NICHD NIH HHS P01 HD003008NIMH NIH HHS P50 MH081756NIMH NIH HHS P50 MH115716NIMH NIH HHS R01 MH087554NIMH NIH HHS R01 MH100182NIMH NIH HHS R01 MH111652
6 · The paper itself

Abstract

objectiveAlthough some eye-tracking studies demonstrate atypical attention to faces by 6 months of age in autism spectrum disorder (ASD), behavioral studies in early infancy return largely negative results. We examined the effects of context and diagnosis on attention to faces during face-to-face live interactions in infants at high familial risk (HR) and low familial risk (LR) for ASD.

methodParticipants were 6-, 9-, and 12-month-old siblings of children with ASD who were later determined to have ASD (n = 21), other developmental challenges (HR-C; n = 74), or typical development (TD) (HR-TD; n = 32), and low-risk, typically developing controls (LR-TD; n = 49). Infants were administered the social orienting probes task, consisting of five conditions: dyadic bid, song, peek-a-boo, tickle, and toy play. Attention to an unfamiliar examiner's face was coded by blinded raters from video recordings.

resultsAt all ages, the ASD group spent less time looking at the examiner's face than the HR-C, HR-TD, and LR-TD groups during the Dyadic Bid and Tickle conditions (all p <.05), but not during the Song, Peek-a-Boo, or Toy Play conditions (all p >.23). Lower attention to faces during Dyadic Bid and Tickle conditions was significantly correlated with higher severity of autism symptoms at 18 months.

conclusionDuring the prodromal stages of the disorder, infants with ASD exhibited subtle impairments in attention to faces of interactive partners during interactions involving eye contact and child-directed speech (with and without physical contact), but not in contexts involving singing, familiar anticipatory games, or toy play. Considering the convergence with eye-tracking findings on limited attention to faces in infants later diagnosed with ASD, reduced attention to faces of interactive partners in specific contexts may constitute a promising candidate behavioral marker of ASD in infancy.

Indexed as

Autism Spectrum DisorderChildHumansInfantRiskSiblingsattentionautisminfancysocial behaviorsocial interaction

Identifiers

PMID32061926
PMCPMC9524139
OpenAlexW3005764200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.