Evidence map›Paper›PMID 32061832›Full record

ArticleExperimental cell research2020

Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity.

Sharada Tilve, Chinyere Agbaegbu Iweka, Jonathan Bao, Natalie Hawken, Caitlin P Mencio, Herbert M Geller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental cell research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Emerging therapeutic targets for neuroblastoma.Expert opinion on therapeutic targets · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sharada TilveLaboratory of Developmental Neurobiology, National Heart Lung and Blood Institute, NIH, Bethesda, MD, 20892, USA.
Chinyere Agbaegbu IwekaLaboratory of Developmental Neurobiology, National Heart Lung and Blood Institute, NIH, Bethesda, MD, 20892, USA; Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA.
Jonathan BaoDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Natalie HawkenLaboratory of Developmental Neurobiology, National Heart Lung and Blood Institute, NIH, Bethesda, MD, 20892, USA.
Caitlin P MencioLaboratory of Developmental Neurobiology, National Heart Lung and Blood Institute, NIH, Bethesda, MD, 20892, USA.
Herbert M GellerLaboratory of Developmental Neurobiology, National Heart Lung and Blood Institute, NIH, Bethesda, MD, 20892, USA. Electronic address: gellerh@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USGeorgetown University · USRensselaer Polytechnic Institute · US

Funding

Signaling by Chondroitin Sulfate ProteoglycansZIAHL006021 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI GELLER, HERBERT M. · 2009 to 2022
$12.3M
Intramural NIH HHS ZIA HL006021
6 · The paper itself

Abstract

Phospholipid Phosphatase-Related Protein Type 1 (PLPPR1) is a six-transmembrane protein that belongs to the family of plasticity-related gene proteins, which is a novel brain-specific subclass of the lipid phosphate phosphatase superfamily. PLPPR1-5 have prominent roles in synapse formation and axonal pathfinding. We found that PLPPR1 overexpression in the mouse neuroblastoma cell line (Neuro2a) results in increase in cell adhesion and reduced cell migration. During migration, these cells leave behind long fibrous looking extensions of the plasma membrane causing a peculiar phenotype. Cells expressing PLPPR1 showed decreased actin turnover and decreased disassembly of focal adhesions. PLPPR1 also reduced active Rac1, and expressing dominant negative Rac1 produced a similar phenotype to overexpression of PLPPR1. The PLPPR1-induced phenotype of long fibers was reversed by introducing constitutively active Rac1. In summary, we show that PLPPR1 decreases active Rac1 levels that leads to cascade of events which increases cell adhesion.

Indexed as

Cell AdhesionFocal AdhesionsGene Expression Regulation, NeoplasticActinsAnimalsCell MovementMembrane ProteinsMiceNeuroblastomaNeuropeptidesPhosphoric Monoester Hydrolasesrac1 GTP-Binding ProteinSignal TransductionTumor Cells, CulturedActinsMembrane ProteinsNeuropeptidesPhosphoric Monoester HydrolasesPlppr1 protein, mouserac1 GTP-Binding ProteinRac1 protein, mouseCell motilityChondroitin sulfate proteoglycansCytoskeletonExtracellular matrixNeuro2a

Identifiers

PMID32061832
PMCPMC7132996
OpenAlexW3006168636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.