ReviewBiological psychiatry2020
Psychosis Risk and Development: What Do We Know From Population-Based Studies?
Review in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Polygenic risk meets early trauma: toward a neuropsychodevelopmental model of schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Article
- Neuropsychology and Neurobiology of Negative Schizotypy: A Selective Review.Biological psychiatry global open science · 2024Review
- A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence.Brain imaging and behavior · 2024Article
- Impaired Sleep Mediates the Relationship Between Interpersonal Trauma and Subtypes of Delusional Ideation.Schizophrenia bulletin · 2024Article
- Medical and Psychiatric Care Preceding the First Psychotic Disorder Diagnosis.Schizophrenia bulletin · 2024Article
- Article
- Reflective functioning and dissociative experiences: A comparison study between adolescents at "high-risk" of psychosis and healthy controls.Health psychology research · 2023Article
- Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.The American journal of psychiatry · 2022Article
- Clinical high-risk criteria of psychosis in 8-17-year-old community subjects and inpatients not suspected of developing psychosis.World journal of psychiatry · 2022Article
- Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.Translational psychiatry · 2021Article
- Preventive psychiatry: a blueprint for improving the mental health of young people.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Adolescent Neurodevelopment and Vulnerability to Psychosis.Biological psychiatry · 2021Review
- Article
- White Matter Microstructure across the Psychosis Spectrum.Trends in neurosciences · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent years have seen an advent in population-based studies in children, adolescents, and adults that examine the prevalence, etiology, and developmental trajectories of diverse subclinical psychopathological symptoms that pose a risk for the later development of severe mental illnesses. It is increasingly recognized that most categorically defined psychiatric disorders occur on a spectrum or continuum, show high heterogeneity and symptom overlap, and share genetic and environmental risk factors. We discuss neurodevelopmental underpinnings of psychosis spectrum symptoms and review brain morphometric and functional alterations as well as genetic liability for psychosis in individuals experiencing psychotic symptoms (PSs) in the general population. With regard to brain structure and function, findings of qualitatively similar alterations in individuals experiencing subthreshold PSs and individuals with overt psychotic disorders support the notion of a psychosis continuum. However, genetic and epidemiological studies have emphasized the overlap of PSs and other psychiatric illnesses. In particular, PSs during adolescence appear to be a nonspecific precursor of different psychopathological outcomes. Given the evidence presented in this review, we argue that findings from population-based studies are appropriate to guide policy-making to further emphasize public health efforts. Broadly accessible mental health programs are promising to make a difference in the field of adolescent mental health. However, the specific efficacy of these programs warrants further study, and caution is advised to not overpathologize potentially transient occurrence of mental health problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.