ArticleMolecular biology and evolution2020
Evolutionary Analysis of the Bacillus subtilis Genome Reveals New Genes Involved in Sporulation.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Effects ofMicroorganisms · 2026Article
- Exploring the lipoproteome of Parageobacillus thermoglucosidasius.Access microbiology · 2026Article
- Gene age and genome organization inFrontiers in microbiology · 2025Article
- Thermal Plasticity and Evolutionary Constraints inBiology · 2024Article
- Genomic characterization of the salt-tolerant3 Biotech · 2024Article
- A model industrial workhorse: Bacillus subtilis strain 168 and its genome after a quarter of a century.Microbial biotechnology · 2023Review
- Pleomorphic Variants ofInternational journal of molecular sciences · 2023Article
- Taxonomically Restricted Genes in Bacillus may Form Clusters of Homologs and Can be Traced to a Large Reservoir of Noncoding Sequences.Genome biology and evolution · 2023Article
- Termination factor Rho mediates transcriptional reprogramming of Bacillus subtilis stationary phase.PLoS genetics · 2023Article
- A novel time-lapse imaging method for studying developing bacterial biofilms.Scientific reports · 2022Article
- New Genes Interacted With Recent Whole-Genome Duplicates in the Fast Stem Growth of Bamboos.Molecular biology and evolution · 2021Article
- No endospore formation confirmed in members of the phylum Proteobacteria.Applied and environmental microbiology · 2021Article
- Embryo-Like Features in Developing Bacillus subtilis Biofilms.Molecular biology and evolution · 2021Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacilli can form dormant, highly resistant, and metabolically inactive spores to cope with extreme environmental challenges. In this study, we examined the evolutionary age of Bacillus subtilis sporulation genes using the approach known as genomic phylostratigraphy. We found that B. subtilis sporulation genes cluster in several groups that emerged at distant evolutionary time-points, suggesting that the sporulation process underwent several stages of expansion. Next, we asked whether such evolutionary stratification of the genome could be used to predict involvement in sporulation of presently uncharacterized genes (y-genes). We individually inactivated a representative sample of uncharacterized genes that arose during the same evolutionary periods as the known sporulation genes and tested the resulting strains for sporulation phenotypes. Sporulation was significantly affected in 16 out of 37 (43%) tested strains. In addition to expanding the knowledge base on B. subtilis sporulation, our findings suggest that evolutionary age could be used to help with genome mining.
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