Evidence map›Paper›PMID 32061007›Full record

ArticleJournal of clinical laboratory analysis2020

Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients.

Yan Zhang, Hongjie Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. The diagnostic and prognostic value of exosomal microRNAs in lung cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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  17. Extracellular vesicles as tools and targets in therapy for diseases.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yan ZhangDepartment of Respiratory Medicine, the Fifth People's Hospital of Wuxi, Wuxi City, China.ORCID https://orcid.org/0000-0001-9310-1211
Hongjie XuDepartment of Respiratory Medicine, the Fifth People's Hospital of Wuxi, Wuxi City, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeregulated circulating microRNAs (miRNAs) are potential biomarkers for the early detection and prognosis prediction of non-small-cell lung cancer (NSCLC). The aim of the present study was to investigate the expression pattern of serum exosomal miR-378 in NSCLC and its correlation with clinical variables.

methodsQuantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to detect serum exosomal miR-378 levels in 103 patients with NSCLC and 60 control subjects.

resultsOur results showed that serum exosomal miR-378 was significantly overexpressed in NSCLC patients, and serum exosomal miR-378 upregulation was clearly associated with positive lymph node metastasis and advanced TNM stage. In addition, receiver operating characteristic (ROC) analysis demonstrated that combination of serum exosomal miR-378 expression and carcinoembryonic antigen (CEA) had a high discriminating power to differentiate NSCLC subjects from controls. Moreover, serum exosomal miR-378 levels in 73 NSCLC cases were significantly decreased after radiotherapy and could be used as an indicator of radiotherapeutic response in NSCLC. Furthermore, survival analyses revealed that patients with higher serum exosomal miR-378 expression had poor overall survival. Multivariate analysis showed that serum exosomal miR-378 expression was independently associated with overall survival.

conclusionsCollectively, serum exosomal miR-378 has strong potential as a promising non-invasive biomarker for screening and monitoring NSCLC.

Indexed as

AdultAgedBiomarkers, TumorCarcinoembryonic AntigenCarcinoma, Non-Small-Cell LungExosomesFemaleGene Expression Regulation, NeoplasticHumansLung NeoplasmsMaleMicroRNAsMiddle AgedPrognosisTreatment OutcomeUp-RegulationBiomarkers, TumorCarcinoembryonic AntigenMicroRNAsMIRN378 microRNA, humanexosomal miR-378non-small-cell lung cancerprognosisserum

Identifiers

PMID32061007
PMCPMC7307377
OpenAlexW3006280012

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.