ArticleMagnetic resonance in medicine2020
Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy).
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Localization-driven exchange contrast in diffusion exchange spectroscopy.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Article
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- The Diffusion Exchange Ratio (DEXR): A minimal sampling of diffusion exchange spectroscopy to probe exchange, restriction, and time-dependence.bioRxiv : the preprint server for biology · 2024Article
- Disentangling the effects of restriction and exchange with diffusion exchange spectroscopy.Frontiers in physics · 2022Article
- Data-Driven multi-Contrast spectral microstructure imaging with InSpect: INtegrated SPECTral component estimation and mapping.Medical image analysis · 2021Article
- Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy).Magnetic resonance in medicine · 2020Article
- Real-time measurement of diffusion exchange rate in biological tissue.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
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Authors and funding
11 authors.
Funding
Abstract
introductionTo combine numerical simulations, in vitro and in vivo experiments to evaluate the feasibility of measuring diffusion exchange across the cell membrane with diffusion exchange spectroscopy (DEXSY).
methodsDEXSY acquisitions were simulated over a range of permeabilities in nerve tissue and yeast substrates. In vitro measurements were performed in a yeast substrate and in vivo measurements in mouse tumor xenograft models, all at 9.4 T.
resultsDiffusion exchange was observed in simulations over a physiologically relevant range of cell permeability values. In vitro and in vivo measures also provided evidence of diffusion exchange, which was quantified with the Diffusion Exchange Index (DEI).
conclusionsOur findings provide preliminary evidence that DEXSY can be used to make in vivo measurements of diffusion exchange and cell membrane permeability.
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